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Podophyllotoxin

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Topoisomerase inhibitor

Potent inhibitor of microtubule assembly. Antineoplastic glucoside. Antitumor agent. DNA topoisomerase II inhibitor.

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Appearance	White to off-white solid.
CAS	518-28-5
Couple Target	Topoisomerase
Couple Type	Inhibitor
Formula	C₂₂H₂₂O₈
Identity	Determined by 1H-NMR and LC-MS.
MI	14: 7546
MW	414.4
Purity	≥98% (HPLC)
RTECS	LV2500000
Solubility	Soluble in chloroform, 100 % ethanol, acetone or dichloromethane; insoluble in water.
Source	Isolated from Podophyllum peltatum.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Very hygroscopic. Protect from moisture. Keep under inert gas.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

An evidence-based review of medical and surgical treatments of genital warts.: N. Scheinfeld & DS. Lehman; Dermatol. Online J. 12, 5 (2006), Abstract
Er:YAG laser followed by topical podophyllotoxin for hard-to-treat palmoplantar warts.: U. Wollina; Cosmet. Laser Ther. 5, 35 (2003), Abstract
Antineoplastic and antiviral activities of podophyllotoxin related lignans: M. Gordaliza, et al.; Arch. Pharmacol. 327, 175 (1994), Abstract
Podophyllotoxin, steganacin and combretastatin: natural products that bind at the colchicine site of tubulin: D.L. Sackett; Pharmacol. Therap. 59, 163 (1993), Abstract
Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents: T. Terada, et al.; Chem. Pharm. Bull. (Tokyo) 40, 2720 (1992), Abstract
Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross- resistance studies with various microtubule inhibitors and podophyllotoxin analogues: R.S. Gupta; Cancer Res. 43, 505 (1983), Abstract

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Topoisomerase II inhibitor

Alternative Name	(5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3’,4’:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 4’-Demethylepipodophyllotoxin-β-D-thenylidine glucoside
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Couple Type	Inhibitor
Purity	≥97% (HPLC)

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