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The polo-like kinases (PLKs) function in cell-cycle progression and in multiple stages of mitosis. PLK1 is activated by phosphorylation of Thr210 at the G2/M phase boundary. Active PLK1 participates in mitotic entry through activation of Cdc25C and nuclear import of cyclin B1, thereby activating the Cdc2/cyclin B kinase.
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Western blot analysis of PLK1 mAb (3F8): Lane 1: MW marker, Lane 2: HeLa, Lane 3: Jurkat, Lane 4: PC-12, Lane 5: 3T3, Lane 6: HEK-293.
| Regulatory Status |
RUO – Research Use Only |
|---|
Related Products
| Application | ELISA, WB |
|---|---|
| Host | Goat |
| Species Reactivity | Mouse |
Last modified: May 29, 2024