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PKG polyclonal antibody

ADI-KAP-PK005

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Cyclic GMP-dependent protein kinases (PKGs or cGKs) are classified into two types, PKGI and PKGII. Studies have shown that PKGs are highly homologous to PKAs; phosphorylation of cellular proteins by both families of kinases leads to alterations in calcium mobilization, protein phosphatase activity, ion channel function, gene transcription, smooth muscle contractility, and platelet aggregation.

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This antibody is covered by our Worry-Free Guarantee.

PKG polyclonal antibody Immunohistochemistry — Immunohistochemistry analysis of human prostate tissue stained with PKG, pAb at 10µg/ml.

PKG polyclonal antibody Western blot — Western blot analysis: Lane 1: MW marker, Lane 2: Mouse Brain Tissue Extract, Lane 3: Rat Brain Tissue Extract, Lane 4: EKS4 Cell Lysate; Lane 5: HS67 Cell Lysate probed with PKG pAb.

ALX-210-099 PDE5A polyclonal antibody Western Blot Rat 1 — The effect of diabetes mellitus and cinaciguat on myocardial NO-sGC-cGMP-PKG signalling. a Relative protein expression and representative immunoblot bands of endothelial nitric oxide synthase (eNOS), soluble guanylate cyclase β1 (sGC β1), phosphodiesterase 5A (PDE-5) (P value of diabetes × treatment interaction in the two-factorial ANOVA, Pinteraction = 0.024), protein kinase G (PKG), vasodilator-stimulated phosphoprotein (VASP) to phospho-VASP (p-VASP) ratio (Pinteraction = 0.003). b Relative gene expression of eNOS (Pinteraction = 0.039). Groups: vehicle-treated control (Co), cinaciguat-treated control (CoCin), vehicle-treated diabetic (DiabCo) and cinaciguat-treated diabetic (DiabCin). Bar graphs represent mean ± SEM of 5–6 experiments per group.*P < 0.05 vs. Co, †P < 0.05 vs. DiabCo (Tukey HSD test)

Image collected and cropped by CiteAb under a CC-BY license from the following publication: The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus. Cardiovasc Diabetol (2015)

Product Details

Alternative Name	Protein kinase G
Application	IHC (PS), WB
Application Notes	Detects a band of ~75kDa by Western blot.
Formulation	Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
GenBank ID	D45864
Host	Rabbit
Immunogen	Synthetic peptide corresponding to a portion of human PKG.
Purity Detail	Protein A affinity purified.
Recommendation Dilutions/Conditions	Western Blot (1:1,000, colorimetric)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from rabbit serum.
Species Reactivity	Human, Mouse, Porcine, Rat
UniProt ID	Q13976
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Salt-sensitive hypertension in GR mutant rats is associated with altered plasma polyunsaturated fatty acid levels and aortic vascular reactivity.: Verouti, S., Aeschlimann, G., et al.; Pflugers Arch. 477, 37 (2025), Application(s): WB, Abstract
Fetal sex and the relative reactivity of human umbilical vein and arteries are key determinants in potential beneficial effects of phosphodiesterase inhibitors.: Peyter, A. C., Beaumann, M., et al.; J. Appl. Physiol. 136, 1526 (2024), Application(s): WB / Reactant(s): Human, Abstract
SUMOylation Modulates Reactive Oxygen Species (ROS) Levels and Acts as a Protective Mechanism in the Type 2 Model of Diabetic Peripheral Neuropathy: Mandel, N., Büttner, M., et al.; Cells 12, (2023), Abstract
Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries: Bai, Y., Li, G., et al.; Am. J. Physiol. Lung Cell. Mol. Physiol. 325, L114 (2023), Abstract
Exercise training rescues impaired H2O2-mediated vasodilation in porcine collateral-dependent coronary arterioles through enhanced K+ channel activation: Johnson, K. A., Jeffery, E., et al.; Am. J. Physiol. Heart Circ. Physiol. 324, H637 (2023), Abstract
LC-MS/MS Validation and Quantification of Cyanotoxins in Algal Food Supplements from the Belgium Market and Their Molecular Origins: F.A. Beñaldo, et al.; Front. Physiol. 13, 864010 (2022), Application(s): WB / Reactant(s) Llama, Abstract
Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signalling.: Hall, E. J., Pal, S., et al.; Cardiovasc. Res. 118, 2124 (2022), Application(s): WB, Abstract
Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation: R.F. Queiroz, et al.; Nat. Commun. 12, 6626 (2021), Application(s): WB, Abstract
Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG: A.C. Balestra, et al.; Sci. Adv. 7, 5396 (2021), Abstract — Full Text
Alteration of the soluble guanylate cyclase system in coronary arteries of high cholesterol diet-fed rabbits: M. Tawa, et al.; Pharmacol. Res. Perspect. 9, e00838 (2021), Reactant(s) Rabbit, Abstract