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Pifithrin-α

BML-GR325

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p53 inhibitor

Chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Suppresses self-renewal of embryonic stem cells.

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Product Details

Alternative Name	1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone . HBr, PFT-α
Appearance	White solid.
CAS	63208-82-2
Couple Target	p53
Couple Type	Inhibitor
Formula	C₁₆H₁₈N₂OS . HBr
MW	367.3
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (>25mg/ml) or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light. Keep under inert gas. Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Limb reduction in an Esco2 cohesinopathy mouse model is mediated by p53-dependent apoptosis and vascular disruption: A.S. Strasser, et l.; Nat. Commun. 15, 7154 (2024), Abstract
Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway: L. L’homme, et al.; Nutrients 12, 3771 (2020), Abstract — Full Text
A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation: Beermann, J., Kirste, D., et al.; Cell Death Differ. 25, 307 (2018), Abstract
Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and β1 integrin/FAK−mediated signalling: M. Klobucar, et al.; Biochem. Biophys. Res. Commun. 503, 843 (2018), Abstract
Inhibition of the Cardiac Fibroblast-Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic Dysfunction: Piccoli, M. T., Gupta, S. K., et al.; Circ. Res. 121, 575 (2017), Abstract
Reactivation of mutant p53 by capsaicin, the major constituent of peppers: Garufi, A., Pistritto, G., et al.; J. Exp. Clin. Cancer Res. 35, 136 (2016), Abstract
Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication: Sifford, J. M., Stahl, J. A., et al.; J. Virol. 90, 2571 (2015), Abstract
Cisplatin-induced renal injury is independently mediated by OCT2 and p53: Sprowl, J. A., Lancaster, C. S., et al.; Clin. Cancer Res. 20, 4026 (2014), Abstract
Dimethylfumarate attenuates restenosis after acute vascular injury by cell-specific and Nrf2-dependent mechanisms: Oh, C. J., Park, S., et al.; Redox Biol. 2, 855 (2014), Abstract
Induction of p53-dependent p21 limits proliferative activity of rat hepatocytes in the presence of hepatocyte growth factor: Inoue, Y., Tomiya, T., et al.; PLoS One 8, e78346 (2013), Abstract

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Last modified: May 29, 2024

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Pifithrin-α

BML-GR325

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