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Phenylmethylsulfonyl fluoride

ALX-270-184

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Inhibitor of serine proteases and FAAH

Irreversible inhibitor of serine proteases. Widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB₁ receptor activity. Spleen membranes used for CB₂ studies do not require this pretreatment, as FAAH activity is absent in these cells. Inhibits also cysteine proteases like papain (reversible by DTT treatment, Prod. No. ALX-280-001), as well as internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor see AEBSF (Prod. No. ALX-270-022).

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Product Details

Alternative Name	PMSF, Benzylsulfonyl fluoride
Appearance	White to off-white needle crystals.
CAS	329-98-6
Couple Target	FAAH, Serine protease
Couple Type	Inhibitor
Formula	C₇H₇FO₂S
MW	174.2
Purity	≥99% (HPLC)
RTECS	XT8040000
Solubility	Soluble in 100% ethanol, methanol or isopropanol; insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Electroacupuncture at GB34 modulates neurogenesis and BDNF-ERK signaling in a mouse model of Parkinson’s disease: Y. Lee, et al.; J. Tradit. Complement. Med. 13, 263 (2023), Abstract
PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing: S. Rajasekaran, et al.; Nucleic Acids Res. 50, 7048 (2022), Abstract
A high spatial resolution osteogenic differentiation in human mesenchymal stem cells induced by femtosecond laser: S. Liu, et al.; J. Biophotononics 15, e202200144 (2022), Abstract
Enhancing the Effect of Placental Extract on the Regeneration of Crush Injured Facial Nerve: G.M. Lim, et al.; Exp. Neurobiol. 31, 419 (2022), Abstract
Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry: L.M.Q. Liao, et al.; J. Vis. Exp. , (2021), Abstract
Angiopoietin-1/Tie-2 signal after focal traumatic brain injury is potentiated by BQ788, an ETB receptor antagonist, in the mouse cerebrum: Involvement in recovery of blood-brain barrier function: Michinaga, S., Tanabe, A., et al.; J. Neurochem. 154, 330 (2020), Abstract
Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ12,14 -PGJ2 and Nogo: Zhang, S., Yu, M., et al.; Br. J. Pharmacol. 177, 1041 (2020), Abstract
Inhibition of Cyclic Adenosine Monophosphate-Specific Phosphodiesterase by Various Food Plant-Derived Phytotherapeutic Agents: T. Röhrig, et al.; Medicines (Basel) 4, 80 (2017), Abstract — Full Text
Identification of Novel Mutations in the LRR-Cap Domain of C21orf2 in Japanese Patients With Retinitis Pigmentosa and Cone-Rod Dystrophy: A. Suga, et al.; Invest. Ophthalmol. Vis. Sci. 57, 4255 (2016), Application(s): Western blot, isolated retina lysates, Abstract — Full Text
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies: I. Albrecht, et al.; J. Clin. Invest. 125, 4612 (2015), Application(s): Skeletal muscle cell culture, Abstract — Full Text

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Phenylmethylsulfonyl fluoride

ALX-270-184

Product Details

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