PCNA recombinant monoclonal antibody (144)

The anti-PCNA antibody detects human Proliferating Cell Nuclear Antigen (PCNA), a key protein involved in DNA replication and repair. This antibody is optimized for applications such as immunohistochemistry (IHC), ELISA, and Western blotting.

Proliferating Cell Nuclear Antigen (PCNA) is a nuclear protein that acts as a processivity factor for DNA polymerase δ during DNA replication. It forms a homotrimeric ring that encircles the DNA, serving as a sliding clamp to enhance the efficiency of DNA synthesis. In addition to its critical role in replication, PCNA is also involved in DNA repair, chromatin remodeling, and cell cycle regulation. PCNA expression is tightly correlated with cellular proliferation and is widely used as a marker for dividing cells in cancer research, developmental biology, and tissue regeneration studies. Its dysregulation has been implicated in tumorigenesis and other diseases associated with genomic instability.