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PARP-2 (mouse), (recombinant) (high purity)

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Alternative Name	Poly(ADP-ribose) polymerase 2
Concentration	~1mg/ml
Formulation	Liquid. In 50mM TRIS-HCl, pH 7.5, containing 1mM DTT, 0.5mM EDTA, 0.5mM PMSF and 20% glycerol.
Purity	≥98% (SDS-PAGE)
Purity Detail	Affinity purified.
Source	Produced in Sf9 insect cells (full length). Produced in a baculovirus expression system.
Specific Activity	≥200U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1nmol of poly(ADP-ribose) per min at 25°C, pH 7.5. See also separate protocol (link below).
UniProt ID	O88554

Regulatory Status	RUO – Research Use Only

TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation: A. Tolić , et al.; Epigenetics Chromatin 15, 11 (2022), Abstract
Quantitative correlation between cellular proliferation and nuclear poly (ADP-ribose) polymerase (PARP-1): E. Kun, et al.; Int. J. Mol. Med. 17, 293 (2006), Abstract
Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing: M. Malanga & F.R. Althaus; J. Biol. Chem. 279, 5244 (2004), Abstract — Full Text
A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA. structure and expression of the mouse PARP-2 gene: J.C. Ame, et al.; J. Biol. Chem. 276, 11092 (2001), Abstract — Full Text
PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase: J.C. Ame, et al.; J. Biol. Chem. 274, 17860 (1999), Abstract — Full Text

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Purity	≥99% (SDS-PAGE)
Source	Purified from calf thymus and activated by digestion with DNAse I.

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