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PARP-1 (human), (recombinant) (high purity)

ALX-201-063

13 citations

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PARP-1 (human), (recombinant) (high purity) image — **Quality Control**: 10% SDS-Polyacrylamide gel.

Product Details

Alternative Name	Poly(ADP-ribose) polymerase 1
Concentration	1mg/ml
Formulation	Liquid. In 100mM TRIS-HCl, pH 7.5, containing 14mM β-mercaptoethanol, 0.5mM EDTA, 0.5mM PMSF and 10% glycerol.
Purity	≥99% (SDS-PAGE)
Purity Detail	Affinity purified.
Source	Produced in Sf9 insect cells. Produced in a baculovirus expression system.
Specific Activity	≥600U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1nmol of poly(ADP-ribose) per min. at 25°C, pH 7.5.
UniProt ID	P09874

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Tankyrase-1 regulates RBP-mediated mRNA turnover to promote muscle fiber formation: Mubaid, S., Sanchez, B. J., et al.; Nucleic Acids Res. 52, 4002 (2024), Abstract
Inhibition of host PARP1 contributes to the anti-inflammatory and antitubercular activity of pyrazinamide: S. Krug, et al.; Nat. Commun. 14, 8161 (2023), Abstract
TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation: A. Tolić , et al.; Epigenetics Chromatin 15, 11 (2022), Abstract
Identification by Inverse Virtual Screening of magnolol-based scaffold as new tankyrase-2 inhibitors: S. Di Micco, et al.; Bioorg. Med. Chem. 26, 3953 (2018), Abstract
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1: L.C. Lehmann, et al.; Mol. Cell 68, 847 (2017), Abstract — Full Text
PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair: Y. Hu, et al.; Cancer Discov. 4, 1430 (2014), Abstract — Full Text
A family of macrodomain proteins reverses cellular mono-ADP-ribosylation: G. Jankevicius, et al.; Nat. Struct. Mol. Biol. 20, 508 (2013), Abstract
Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription: T. Wu, et al.; Free Radic. Biol. Med. 67C, 69 (2013), Abstract
Mapping PARP-1 auto-ADP-ribosylation sites by liquid chromatography-tandem mass spectrometry: J.D. Chapman, et al.; J. Proteome Res. 12, 1868 (2013), Abstract
Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis: C. Leptrête, et al.; Int. J. Biochem. Cell Biol. 41, 1046 (2009), Abstract

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PARP-1 (human), (recombinant) (high purity)

ALX-201-063

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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