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Paroxetine is a highly potent and selective serotonin (5-HT) uptake inhibitor. It acts by binding to the serotonin transporter (SERT) with high affinity (Ki = 05 nM). In vitro paroxetine competitively inhibits the uptake of 5-HT by rat hypothalamic and cortical synaptosomes with only very weak effects on noradrenaline and dopamine uptake. Paroxetine is in clinical use for the treatment of depression, anxiety and other disorders.
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