NU1025

ALX-270-370

Datasheet
Manual
SDS
CofA

Already have an account?

PARP-1 inhibitor

A potent poly(ADP-ribose) polymerase 1 (PARP-1) inhibitor (IC₅₀=400nM) that potentiates the cytotoxicity of various DNA-active agents, including the DNA-methylating compound MTIC, the DNA strand break-inducing drug temozolomide (Prod. No. ALX-420-044), topotecan (Prod. No. ALX-350-133), bleomycin (Prod. No. BML-AP302), and ionizing radiation effective in murine L1210 leukemia cells, CHO, and in a variety of human tumor cell lines.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	8-Hydroxy-2-methylquinazoline-4-one
Appearance	Off-white to purple solid.
CAS	90417-38-2
Couple Target	PARP
Couple Type	Inhibitor
Formula	C₉H₈N₂O₂
MW	176.2
Purity	≥98% (HPLC)
Reconstitution	Reconstitute with DMSO.
Solubility	Soluble in DMSO (25mg/ml). This solution can be further diluted 1:100 in tissue culture medium before use.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
Short Term Storage	-20°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei: M. Schlesinger, et al.; Parasit. Vectors 9, 173 (2016), Application(s): Potency of inhibitors, Abstract — Full Text
Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin: Robert, C., Nagaria, P. K., et al.; Leuk. Res. Treatment 45, 14 (2016), Abstract
The properties of tumor-initiating cells from a hepatocellular carcinoma patient’s primary and recurrent tumor: X.L. Xu, et al.; Carcinogenesis 31, 167 (2010), Abstract — Full Text
Role of SIRT1 in homologous recombination: M. Uhl, et al.; DNA Repair (Amst) 9, 383 (2010), Abstract
3-Methylindole is mutagenic and a possible pulmonary carcinogen: J.M. Weems, et al.; Toxicol. Sci. 112, 59 (2009), Abstract — Full Text
Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines: C.A. Delaney, et al.; Clin. Cancer Res. 6, 2860 (2000), Abstract — Full Text
Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage: S. Boulton, et al.; Carcinogenesis 20, 199 (1999), Abstract — Full Text
Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064: K.J. Bowman, et al.; Br. J. Cancer 78, 1269 (1998), Abstract
Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP): R.J. Griffin, et al.; J. Med. Chem. 41, 5247 (1998), Abstract
Nephron-sparing surgery for renal cell carcinoma: J.H. Griffin & R.C. Flanigan; Tech. Urol. 2, 43 (1996), Abstract