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Bleomycin sulfate

BML-AP302

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Antitumor antibiotic

Antibiotic with anti-cancer and apoptotic properties
Radiomimetic DNA-cleaving agent that produces double and single DNA strand breaks through an oxygen-radical-dependent mechanism
Highly cited

Bleomycin consists in a complex of 11 glycopeptide anti-cancer antibiotics originally isolated from Streptomyces verticillus. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycin has found clinical application in the treatment of a range of tumors. Bleomycin acts by intercalation of DNA and RNA. In the presence of oxygen and metal ions (e.g. copper and iron), Bleomycin forms a pseudo-enzyme that induces DNA cleavage.

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Product Details

Alternative Name	Blenoxane
Appearance	White crystalline solid.
CAS	9041-93-4
Formula	C₅₅H₈₅N₁₇O₂₁S₃(For A2)
MI	14: 1318
MW	1415.6 (For A2)
Purity	≥98% (HPLC)
RTECS	EC5991990
Solubility	Soluble in 100% methanol or water (20mg/ml).
Source	Isolated from Streptomyces sp.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Deregulated immune cell recruitment orchestrated by c-MET impairs pulmonary inflammation and fibrosis: Barbosa-Matos, C., Borges-Pereira, C., et al.; Respir. Res. 25, 257 (2024), Abstract
Interstitial Macrophages Lead Early Stages of Bleomycin-Induced Lung Fibrosis and Induce Fibroblasts Activation: Libório-Ramos, S., Barbosa-Matos, C., et al.; Cells 12, (2023), Abstract
Skin fibrosis and recovery is dependent on Wnt activation via DPP4: A. Jussila, et al.; J. Invest. Dermatol. 142, 1597 (2022), Abstract
Inhibiting a mRNA motif binding protein that mediates TGF-β1 upregulation of translation attenuates pulmonary fibrosis in mice: Chen, W., Pilling, D., et al.; bioRxiv , (2022)
A Proximity Ligation Method to Detect Proteins Bound to Single-Stranded DNA after DNA End Resection at DNA Double-Strand Breaks: F.C. Fowler & J.K. Tyler; Methods Protoc. 5, 3 (2022), Abstract
Ameliorating Fibrosis in Murine and Human Tissues with END55, an Endostatin-Derived Fusion Protein Made in Plants: L. Mlakar, et al.; Biomedicines 10, 2861 (2022), Abstract
A model of the aged lung epithelium in idiopathic pulmonary fibrosis: H. Shaghaghi, et al.; Aging 13, 16922 (2021), Abstract — Full Text
Discovery of the S1P2 antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a preclinical candidate for the treatment of idiopathic pulmonary fibrosis: O. Mammoliti, et al.; J. Med. Chem. 64, 6037 (2021), Abstract
Adipocyte lipolysis abrogates skin fibrosis in a Wnt/DPP4-dependent manner: Jussila, A., Caves, E., et al.; bioRxiv , (2021)
Impaired HSF1 transactivation drives proteostasis collapse and senescent phenotype of IPF lung fibroblast: Cuevas-Mora, K., Roque, W., et al.; bioRxiv , (2020)