NSC-95397

BML-EI309

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CDC25 inhibitor

A potent and selective inhibitor of Cdc25 phosphatase (K_i‘s for Cdc25A, B and C are 32, 96 and 40 nM respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.

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Product Details

Appearance	Orange crystalline solid.
CAS	93718-83-3
Couple Target	CDC25, Dual specificity phosphatase
Couple Type	Inhibitor
Formula	C₁₄H₁₄O₄S₂
MW	310.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (50mM) or ethanol (5mM).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment: D’Alessandro, G., Grimaldi, A., et al.; Oncotarget 7, 30781 (2016), Abstract
Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors: J. S. Lazo, et al.; Mol. Pharmacol. 61, 720 (2002), Abstract — Full Text

Last modified: May 29, 2024

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NSC-95397

BML-EI309

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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