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Nodularin (linear)

ALX-350-182

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Precursor of the highly toxic cyclic pentapeptide, nodularin.

Linear nodularin has been demonstrated to be a biosynthetic precursor of the highly toxic cyclic pentapeptide, nodularin. It is an intermediate of biodegradation by natural populations of bacteria in aquatic samples.

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Product Details

Appearance	Pale powder or an oil (film), depending on the lot.
Couple Target	Serine/threonine-protein phosphatase
Couple Type	Inhibitor
Formula	C₄₁H₆₂N₈O₁₁
Identity	Identity determined by MS.
MW	843.0
Purity	≥95% (HPLC)
RTECS	GU2294250
Solubility	Soluble in methanol:water (1:1).
Source	Isolated from Nodularia spumigena.
Technical Info / Product Notes	Not toxic to mice at 2 mg/kg I.P.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

An ELISA-based Method for Variant-independent Detection of Total 3 Microcystins and Nodularins via Multi-immunogen Approach: J. Liu, et al.; Environ. Sci. Technol. 55, 12984 (2021), Abstract
Biodegradation of microcystins and nodularin in freshwaters: C. Edwards, et al.; Chemosphere 73, 1315 (2008), Abstract
Nodularin-induced genotoxicity following oxidative DNA damage and aneuploidy in HepG2 cells: A. Lankoff, et al.; Toxicol. Lett. 164, 239 (2006), Abstract
Characterization of nodularin variants in Nodularia spumigena from the Baltic Sea using liquid chromatography/mass spectrometry/mass spectrometry: H. Mazur-Marzec, et al.; Rapid Commun. Mass Spectrom. 20, 2023 (2006), Abstract
Bacterial degradation of microcystins and nodularin: S. Imanishi, et al.; Chem. Res. Toxicol. 18, 591 (2005), Abstract
New Nodularins: A General Method for Structure Assignment: M. Namikoshi, et al.; J. Org. Chem. 59, 2349 (1994), Full Text
Structure and Biosynthesis of toxins from blue-green algae: K.L. Rinehart, et al.; J. Appl. Phycol. 6, 159 (1994)
Isolation of linear peptides related to the hepatotoxins nodularin and microcystins: B.W. Choi, et al; Tetrahed. Lett. 34, 7881 (1993)

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Nodularin (linear)

ALX-350-182

Product Details

Handling & Storage

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