Nestin monoclonal antibody (11)

The anti-Nestin antibody detects human Nestin, a key intermediate filament protein expressed in neural stem cells and progenitors. This antibody is optimized for applications such as immunohistochemistry (IHC), flow cytometry, and Western blotting (WB), making it an essential choice for studying neural development, regeneration, and stem cell biology.

Nestin is a type VI intermediate filament protein prominently expressed in neural stem cells and progenitors during embryonic development. It plays a crucial role in maintaining the structural integrity and dynamic remodeling of the cytoskeleton in rapidly dividing cells. As development progresses, Nestin expression diminishes in mature neurons and glial cells, making it a hallmark of neural stem and progenitor cells. Beyond the nervous system, Nestin is expressed in other stem or progenitor cell types during development and regeneration, such as in muscle and endothelial cells. Its re-expression has been observed in pathological conditions like glioblastoma and other cancers, where it is associated with tumor proliferation and plasticity.