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Product Details
| Alternative Name |
Multidrug resistance-associated protein 2, cMOAT, ABCC2 |
|---|---|
| Application |
ICC, IHC (FS), IHC (PS), WB |
| Application Notes |
Immunocytochemistry: cytospin preparations |
| Clone |
M2III-5 |
| Crossreactivity |
Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, MRP1, MRP3 or MRP5. |
| Formulation |
Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide. |
| Host |
Mouse |
| Immunogen |
Recombinant C-terminal rat MRP2 (multidrug resistance-associated protein 2; cMOAT) (aa 1339-1541). |
| Isotype |
IgG2b |
| Recommendation Dilutions/Conditions |
Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.Immunohistochemistry (frozen sections, paraffin sections): Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex or on paraffin sections after pretreatment with 0.01 M citric acid, pH 6.0 in distilled water at 100°C for 5 min 3 times. After washing, slides can be incubated with biotinylated rabbit anti-mouse IgG and streptavidin conjugated to horseradish peroxidase.Western Blot: Use 1:20-1:50 dilution and anti-mouse-HRP.Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Species Reactivity |
Human, Mouse, Rat |
| Specificity |
Recognizes an internal epitope of MRP2. |
| UniProt ID |
Q63120 |
| Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
| Short Term Storage |
+4°C |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Multidrug Resistance-Associated Protein 2 Deficiency Aggravates Estrogen-Induced Impairment of Bile Acid Metabolomics in Rats.: Alaei Faradonbeh, F., Lastuvkova, H., et al.; Front. Physiol. 13, 859294 (2022), Reactant(s): Rat, Abstract
- In Vitro Transport Activity and Trafficking of MRP2/ABCC2 Polymorphic Variants: Wen, X., Joy, M. S., et al.; Pharm. Res. 34, 1637 (2017), Abstract
- Boldine enhances bile production in rats via osmotic and Farnesoid X receptor dependent mechanisms: J. Cermanova, et al.; Toxicol. Appl. Pharmacol. 285, 12 (2015), Application(s): Western Blotting, Immunohistochemistry, Abstract
- Maternal bile acid transporter deficiency promotes neonatal demise: Y. Zhang, et al.; Nat. Commun. 6, 8186 (2015), Application(s): Immunoblot analysis of tissue homogenates, Abstract
- Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells: Marquez, B., Caceres, N. E., et al.; Antimicrob. Agents Chemother. 53, 2410 (2009), Abstract
- Analysis of the in vivo functions of Mrp3: M.G. Belinsky, et al.; Mol. Pharmacol. 68, 160 (2005), Abstract
- Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000), Abstract — Full Text
- Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene: C.C. Paulusma, et al.; Science 271, 1126 (1996), Abstract
Last modified: May 29, 2024
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