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Mitoxantrone . dihydrochloride

ALX-400-050

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DNA intercalator and Topoisomerase II inhibitor

Antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Has been shown to be an inhibitor of DNA methylation.

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Product Details

Alternative Name	1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione . dihydrochloride
Appearance	Blue to black crystalline solid.
CAS	70476-82-3
Couple Target	Topoisomerase
Couple Type	Inhibitor
Formula	C₂₂H₂₈N₄O₆. 2HCl
Identity	Determined by IR.
MI	14: 6217
MW	444.5 . 73.0
Purity	≥97% (Assay)
RTECS	CB5748500
Solubility	Soluble in water; slightly soluble in 100% ethanol or methanol; insoluble in acetonitrile or acetone.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibitory Effect of Mitoxantrone on Collagen Synthesis in Dermal Fibroblasts: K. Kim, et al.; Ann. Dermatol. 34, 206 (2022), Abstract
Direct modification of the 5-HT3 receptor current by some anticancer drugs: Y. Nakamura, et al.; Eur. J. Pharmacol. 821, 21 (2017), Abstract
Increased Systemic Exposure of Methotrexate by a Polyphenol-Rich Herb via Modulation on Efflux Transporters Multidrug Resistance-Associated Protein 2 and Breast Cancer Resistance Protein: C.P. Yu, et al.; J. Pharm. Sci. 105, 343 (2016), Application(s): Used as a probe substrate for evaluating the activity of BCRP, Abstract
A molecular understanding of mitoxantrone-DNA adduct formation: effect of cytosine methylation and flanking sequences: B.S. Parker, et al.; J. Biol. Chem. 279, 18814 (2004), Abstract — Full Text
A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone: J. Blasiak, et al.; Acta Biochim. Pol. 49, 145 (2002), Abstract — Full Text
Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells: A. Skladanowski & J. Konopa; Br. J. Cancer 82, 1300 (2000), Abstract
Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer: D. Faulds, et al.; Drugs 41, 400 (1991), Abstract

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Mitoxantrone . dihydrochloride

ALX-400-050

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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