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DNA synthesis inhibitor
Antitumor antibiotic. DNA crosslinking and damaging agent. Inhibitor of DNA synthesis, nuclear division and cancer cells. DNA intercalating agent. Induces apoptosis in a variety of cells via a p53-dependent pathway.
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Product Details
| Appearance |
Blue-violet solid. |
|---|---|
| CAS |
50-07-7 |
| Couple Target |
DNA |
| Couple Type |
Ligand |
| Formula |
C15H18N4O5 |
| MI |
14: 6215 |
| MW |
334.3 |
| Purity |
≥95% (HPLC) |
| RTECS |
CN0700000 |
| Solubility |
Soluble in water (1mg/ml, warm), 100% ethanol (1mg/ml, warm), DMSO (15mg/ml) or methanol. |
| Technical Info / Product Notes |
Note: Product is not sterile. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -20°C. Stock solutions in water or ethanol are stable for up to 1 week at -20°C. Stock solutions in DMSO are stable for up to 1 month at -20°C. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Survivin modulates stiffness-induced vascular smooth muscle cell motility: Mousso, T., Rice, K., et al.; APL Bioeng. 9, 026120 (2025), Abstract
- Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence: Hastie, K. M., Yu, X., et al.; Cell Rep. 42, 112421 (2023), Abstract
- Survivin as a mediator of stiffness-induced cell cycle progression and proliferation of vascular smooth muscle cells: J.C. Biber, et al.; APL Bioeng. 7, 046108 (2023), Abstract
- Implications of the Wilms’ Tumor Suppressor Wt1 in Cardiomyocyte Differentiation: Wagner, N., Ninkov, M., et al.; Int. J. Mol. Sci. 22, (2021), Abstract
- Relevance of Neurotrophin Receptors CD271 and TrkC for Prognosis, Migration, and Proliferation in Head and Neck Squamous Cell Carcinoma: Foerster, Y., Stöver, T., et al.; Cells 8, (2019), Abstract
- Membrane-bound p35 Subunit of IL-12 on Tumor Cells is Functionally Equivalent to Membrane-bound Heterodimeric Single Chain IL-12 for Induction of Anti-tumor Immunity: H.J. Kim, et al.; Immune Netw. 16, 305 (2016), Application(s): Proliferation of ConA-activated splenocytes, Abstract — Full Text
- Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair: Croglio, M. P., Haake, J. M., et al.; Oncotarget 7, 13984 (2016), Abstract
- PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype: S. Duan, et al.0; Nat. Commun. 6, 10068 (2015), Application(s): Cell culture, MMC selectively killed PTEN-deficient NSCs, Abstract
- Keratinocyte nicotinic acetylcholine receptor activation modulates early TLR2-mediated wound healing responses: M. Kishibe, et al.; Int. Immunopharmacol. 29, 63 (2015), Application(s): Cell Culture, Abstract
- A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial associated necrosis in breast cancer: A. Bastian, et al.; J. Pharmacol. Exp. Ther. 353, 392 (2015), Application(s): Assay, Abstract — Full Text
- The novel function of OCT4B isoform-265 in genotoxic stress: Y. Gao, et al.; Stem Cells 30, 665 (2012), Abstract — Full Text
- Activation of the S phase DNA damage checkpoint by mitomycin C: E. Mladenov, et al.; J. Cell. Physiol. 211, 468 (2007), Abstract
- Re-evaluation of tumor-specific cytotoxicity of mitomycin C, bleomycin and peplomycin: M. Sasaki, et al.; Anticancer Res. 26, 3373 (2006), Abstract
- DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling: A.R. Tee & C.G. Proud; Oncogene 19, 3021 (2000), Abstract
- Selective inhibition of cyclooxygenase-2 enhances mitomycin-C-induced apoptosis: C.T. Hsueh, et al.; Cancer Chemother. Pharmacol. 45, 389 (2000), Abstract
- Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95- independent manner in human gastric adenocarcinoma cells: I.C. Park, et al.; Cancer Lett. 158, 125 (2000), Abstract
- Mitomycins: J. Verweij, et al.; Cancer Chemother. Biol. Response Modif. 18, 46 (1999), Abstract
- p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin: G.R. Merlo, et al.; J. Cell Biol. 128, 1185 (1995), Abstract
- Genetic evidence for an activator required for induction of pectin lyase in Erwinia carotovora subsp. carotovora by DNA-damaging agents: J.L. McEvoy, et al.; J. Bacteriol. 174, 5471 (1992), Abstract
- Elevated DT-diaphorase activity and messenger RNA content in human non- small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cl: A.M. Malkinson, et al.; Cancer Res. 52, 4752 (1992), Abstract
- Polyoxyethylene-modified superoxide dismutase reduces side effects of adriamycin and mitomycin C: S. Kawasaki, et al.; J. Cancer Res. 83, 899 (1992), Abstract
- DNA sequence specificity of mitomycin cross-linking: S.P. Teng, et al.; Biochemistry 28, 3901 (1989), Abstract
- The chemistry of DNA modification by antitumor antibiotics: J.F. Fisher & P.A. Aristoff; Prog. Drug Res. 32, 411 (1988), Abstract
- Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA: M. Tomasz, et al.; Science 235, 1204 (1987), Abstract
- Sequence-specific DNA damage induced by reduced mitomycin C and 7-N-(p- hydroxyphenyl)mitomycin C: K. Ueda and T. Komano; Nucl. Acids Res. 12, 6673 (1984), Abstract
- Revised absolute configuration of mitomycin C. X-ray analysis of 1-N-(p-bromobenzoyl)mitomycin C: K. Shirahata & N. Hirayama; JACS 105, 7199 (1983)
- Mitomycin C. Current Status and New Developments: S.K. Carter & S.T. Crooke; Academic Press, New York , (1979), (Book)
- Mitomycin, a new antibiotic from Streptomyces. I: T. Hata, et al.; J. Antibiot. (Tokyo) 9, 141 (1956), Abstract
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