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Lysine-specific demethylase 1 (LSD1, AOF2, BHC110) is a nuclear amine oxidase homolog, and was the first such protein to display definitive activity in epigenetic modulation as a histone demethylase. LSD1 demethylates histone H3 at mono- or di-methylated lysine residues. Depending on associated co-factors, LSD1-mediated demethylation can lead to transcriptional repression or activation.
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Western blot analysis of LSD1/AOF2 using HeLa and NIH/3T3 cell extracts. Lane 1: Molecular Weight Markers, Lane 2: HeLa, Lane 3: NIH/3T3.
| Regulatory Status |
RUO – Research Use Only |
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Last modified: May 29, 2024