LPS from Salmonella minnesota S-Form (TLRGRADE^®) (Ready-to-Use)

Specific activator of Toll-like receptor 4 (TLR4). Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice. Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.

Lipopolysaccharide from Salmonella minnesota S-Form

TLR, TLR4

Activator, Ligand

Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.

Absence of detectable protein or DNA contaminants with agonistic TLR activity.

Smooth (S)-form LPS isolated and purified from Salmonella minnesota (wild type) by the hot phenol-water method and dissolved in sterile pyrogen-free double distilled water.