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Lovastatin

BML-G226

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HMG-CoA reductase inhibitor

Inhibits cholesterol/isoprenoid biosynthesis by inhibition of HMG-CoA reductase (K_i for acid form is 1nM) and blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Causes cells to arrest early in the G1 phase. Induces apoptosis in cancer cells.

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Product Details

Alternative Name	Mevinolin, 6-α-Methylcompactin
Appearance	White solid.
CAS	75330-75-5
Couple Target	HMG-CoA reductase
Couple Type	Inhibitor
Formula	C₂₄H₃₆O₅
MI	14: 5586
MW	404.6
Solubility	Soluble in DMSO (>25mg/ml) or 100% ethanol (>35mg/ml); insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Pitavastatin Is a Highly Potent Inhibitor of T-Cell Proliferation: L. Voss, et al.; Pharmaceuticals (Basel) 14, 727 (2021), Abstract
MyoScreen, a High-Throughput Phenotypic Screening Platform Enabling Muscle Drug Discovery: Young, J., Margaron, Y., et al.; SLAS Discov. 23, 790 (2018), Abstract
Targeting of PHOX2B expression allows the identification of drugs effective in counteracting neuroblastoma cell growth: E. D. Zanni, et al.; Oncotarget 8, 70695 (2017), Abstract — Full Text
Membrane Cholesterol Modulates LOX-1 Shedding in Endothelial Cells: M. Gioia, et al.; PLoS One 10, e0141270 (2015), Application(s): Cell Culture, Abstract — Full Text
In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells: Jiang, P., Mukthavaram, R., et al.; Br. J. Cancer 111, 1562 (2014), Abstract
Valproic acid overcomes transforming growth factor-β-mediated sorafenib resistance in hepatocellular carcinoma: Matsuda, Y., Wakai, T., et al.; Int. J. Clin. Exp. Pathol. 7, 1299 (2014), Abstract
Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines: Yamamoto, K. N., Hirota, K., et al.; Environ. Mol. Mutagen 52, 547 (2011), Abstract
Breast cancer growth prevention by statins: Campbell, M. J., Esserman, L. J., et al.; Cancer Res. 66, 8707 (2006), Abstract
Statins as a newly recognized type of immunomodulator: B. Kwak, et al.; Nat. Med. 6, 1399 (2000), Abstract
Cell cycle-specific effects of lovastatin: M. Jakobisiak, et al.; Proc. Natl. Acad. Sci. USA 88, 3628 (1991), Abstract

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Lovastatin

BML-G226

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