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L-Theanine

ALX-106-042

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Glutamate receptor ligand

Amino acid analog of glutamine, uniquely found in green tea. Increases brain serotonin, dopamine and GABA levels and binds to AMPA, kainate and NMDA receptors. Has been shown to exert neuroprotective effects in animal models possibly through its antagonistic effects on group 1 metabotrophic glutamate receptors. Behavioural studies with rats suggest L-Theanine to positiveley affect learning and memory processes. Promotes self-renewal of human embryonic stem cells.

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Product Details

Alternative Name	Nγ-Ethyl-L-glutamine, L-Glutamic acid γ-(ethylamide)
Appearance	White to off-white solid.
CAS	3081-61-6
Couple Target	AMPA receptor, Kainate receptor, Metabotropic glutamate receptor, NMDA receptor
Couple Type	Inhibitor, Ligand
Formula	C₇H₁₄N₂O₃
MW	174.20
Purity	≥98% (Titration)
Solubility	Soluble in water (50mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from moisture.
Long Term Storage	+4°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Distribution and biosynthesis of theanine in Theaceae plants.: W.W. Deng, et al.; Plant Physiol. Biochem. 48, 70 (2009), Abstract
Effects of theanine, a unique amino acid in tea leaves, on memory in a rat behavioral test.: T. Yamada, et al.; Biosci. Biotechnol. Biochem. 72, 1356 (2008), Abstract
Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents.: T. Sugiyama & Y. Sadzuka; Biochim. Biophys. Acta 1653, 47 (2003), Abstract
Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors.: T. Kakuda, et al.; Biosci. Biotechnol. Biochem. 66, 2683 (2002), Abstract

Last modified: May 29, 2024

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L-Theanine

ALX-106-042

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