JZL-184

BML-EI391

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Monoacylglycerol lipase inhibitor

Potent, selective and irreversible inhibitor of MAG lipase (IC₅₀=8nM vs 4µM for FAAH). JZL-184-treated mice displayed a number of CB1-dependent behavioral effects including analgesia, hypothermia and hypomotility as well as increased levels of 2-arachidonoylglycerol in the brain ( approx. 8-fold, with no effect on anandamide levels). JZL-184 produces a rapid and sustained blockade of brain 2-AG hydrolase activity in mice. It blocks neuropathic pain and enhances retrograde endocannabinoid signaling.

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Product Details

Alternative Name	4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate
Appearance	Off-white solid.
CAS	1101854-58-3
Couple Target	Monoacylglycerol lipase
Couple Type	Inhibitor
Formula	C₂₇H₂₄N₂O₉
Identity	Determined by NMR.
MW	520.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (10mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects: J.Z. Long, et al.; Nat. Chem. Biol. 5, 37 (2009), Abstract
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain: S.G. Kinsey, et al.; J. Pharmacol. Exp. Ther. 330, 902 (2009), Abstract
Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling: B. Pan, et al.; J. Pharmacol. Exp. Ther. 331, 591 (2009), Abstract

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JZL-184

BML-EI391

Product Details

Handling & Storage

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