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Indomethacin

ALX-270-086

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COX-1 inhibitor. PPAR activator.

Non-steroidal anti-inflammatory and analgesic agent. Inhibits cyclooxygenase (IC₅₀=0.1µM) selectively over lipoxygenases (IC₅₀=100µM for 5-, 12- and 15-LO). Preferentially inhibits PGH synthase-1 over PGH synthase-2 (ID₅₀=4.9-8.1 and 130-160µM respectively). Activates PPARα and γ receptors and induces adipocyte differentiation (EC₅₀=8µM). A clinically useful NSAID.

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Product Details

Appearance	White to light yellow to light orange powder.
CAS	53-86-1
Couple Target	COX, PPAR
Couple Type	Activator, Inhibitor
Formula	C₁₉H₁₆ClNO₄
MI	14: 4968
MW	357.8
Purity	≥98% (HPLC)
Solubility	Soluble in acetone or methanol; insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature – Dangerous Good

Regulatory Status	RUO – Research Use Only

A novel metacyte metafer classifier for platelet morphology using long COVID as a model: Venter, C., Pretorius, J. H., et al.; J. Thromb. Thrombolysis , (2025), Abstract
Following the cellular itinerary of renal aquaporin-2 shuttling with 4.5 x expansion microscopy: F.H. Login, et al.; Am. J. Physiol. Cell Physiol. 326, C194 (2024), Abstract
Novel signalling pathways in nephrogenic syndrome of inappropriate antidiuresis: functional implication of site-specific AQP2 phosphorylation: M. Venneri, et al.; J. Physiol. , (2023), Abstract
A versatile aquaporin-2 cell system for quantitative temporal expression and live cell imaging: M.R. Holst & L.N. Nejsum; Am. J. Physiol. Renal Physiol. 317, F124 (2019), Application(s): Stimulation of FTM cells in cell culture, Abstract
p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity: Molchadsky, A., Ezra, O., et al.; Cell Death Differ. 20, 774 (2013), Abstract
Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs: J.M. Lehmann, et al.; J. Biol. Chem. 272, 3406 (1997), Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994), Abstract
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs: E.A. Meade, et al.; J. Biol. Chem. 268, 6610 (1993), Abstract
Effects of indomethacin on fetal renal function, renal and umbilicoplacental blood flow and lung liquid production: K.M. Stevenson & E.R. Lumbers; J. Dev. Physiol. 17, 257 (1992), Abstract
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostaglandins Leukot. Med. 13, 53 (1984), Abstract

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Last modified: May 29, 2024

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Indomethacin

ALX-270-086

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