Non-steroidal anti-inflammatory and analgesic agent. Inhibits cyclooxygenase (IC50=0.1µM) selectively over lipoxygenases (IC50=100µM for 5-, 12- and 15-LO). Preferentially inhibits PGH synthase-1 over PGH synthase-2 (ID50=4.9-8.1 and 130-160µM respectively). Activates PPARα and γ receptors and induces adipocyte differentiation (EC50=8µM). A clinically useful NSAID.
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Regulatory Status |
RUO – Research Use Only |
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