HA14-1

ALX-430-101

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Bcl-2 ligand

Cell permeable, low molecular weight Bcl-2 ligand. Antagonizes the function of Bcl-2 and induces apoptosis. In HL-60 cells, HA4-1 (50µM and 4h incubation) induced apoptosis of more than 90% of the cells. Apoptosis is blocked by ZVAD-FM. IC₅₀ = ~9µM for competition with Flu-BakBH3 binding to Bcl-2.

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Product Details

Alternative Name	Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
Appearance	Off-white to light yellow powder.
CAS	65673-63-4
Couple Target	Bcl-2
Couple Type	Ligand
Formula	C₁₇H₁₇BrN₂O₅
Identity	Identity determined by IR, 1H-NMR.
MW	409.2
Purity	≥95% (TLC)
Solubility	Soluble in DMSO (25mg/ml), dimethyl formamide or halogenated solvents; also soluble in 100% ethanol (25mg7ml, hot).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Unstable in solution. Prepare fresh solution for each application.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma: Zhang, Y., Zhou, L., et al.; Oncotarget 8, 59476 (2017), Abstract
Artesunate induces apoptosis via a ROS-independent and Bax-mediated intrinsic pathway in HepG2 cells: G. Qin, et al.; Exp. Cell Res. 336, 308 (2015), Application(s): Cell Culture, Abstract
Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis: Schwartz, C., Willebrand, R., et al.; Blood 125, 3896 (2015), Abstract
Towards an understanding of apoptosis detection by SYTO dyes: Wlodkowic, D., Skommer, J., et al.; Cytometry A 71, 61 (2007), Abstract
Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia: M. Milella, et al.; Blood 99, 3461 (2002), Abstract
Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis: D. Liu & Z. Huang; Apoptosis 6, 453 (2001), Abstract
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells: J.L. Wang, et al.; PNAS 97, 7124 (2000), Abstract