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ERp72 polyclonal antibody

ADI-SPS-720

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Endoplasmic reticulum protein (ERp) 72, a 72 kDa protein localized to the endoplasmic reticulum, is a member of the Protein Disulfide Isomerase (PDI) family of proteins. Together with other ER resident proteins such as BiP, GRP94, and PDI, they serve as the molecular chaperones for proper folding of newly translocated and glycolsylated proteins such as Thyroglobulin (Tg) and Human chorionic gonadotropin (hCG)-beta.

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This antibody is covered by our Worry-Free Guarantee.

ERp72 polyclonal antibody Immunohistochemistry — IHC Analysis: Human testis tissue stained with ERp72, pAb at 10µg/ml.

ERp72 polyclonal antibody Western blot — Western blot analysis of ERp72: Lane 1: MW Marker, Lane 2: Rat Liver Microsome Extract, Lane 3: Mouse Liver Microsome Extract, Lane 4: Human Liver Microsome Extract.

Product Details

Alternative Name	PDIA4, ERP70, protein disulfide isomerase
Application	IF, IHC (PS), WB
Application Notes	Detects a band of ~72kDa by Western blot.
Formulation	Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Host	Rabbit
Immunogen	Synthetic peptide corresponding to aa 623-638 of mouse ERp72.
Purity Detail	Protein A affinity purified.
Recommendation Dilutions/Conditions	Western Blot (1:1,000, colorimetric)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from rabbit serum.
Species Reactivity	Bovine, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Rabbit, Rat
Technical Info / Product Notes	Recommended by the Human Protein Atlas Organization for IHC (Ensembl No. ENSG00000155660).
UniProt ID	P08003
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis: Hazari, Y., Urra, H., et al.; bioRxiv , (2023)
EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD: G. George, et al.; Elife 9, e53455 (2020), Abstract — Full Text
Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: role of glycoprotein-specific thiol oxidoreductase ERp57: S. Piacentini, et al.; Sci. Rep. 8, 10425 (2018), Abstract — Full Text
Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response: P. Gomez-Fernandez, et al.; Front. Immunol. 9, 2934 (2018), Application(s): ICC-IF / Reactant(s) Human, Abstract — Full Text
Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE: L.F. Zacchi, et al.; Dis. Model. Mech. 10, 1129 (2017), Abstract — Full Text
A Bi-fluorescence complementation system to detect associations between the Endoplasmic reticulum and mitochondria.: Harmon, M., Larkman, P., et al.; Sci. Rep. 7, 17467 (2017), Application(s): ICC-IF / Reactant(s): Green monkey, Human, Abstract
Redox sensitivities of global cellular cysteine residues under reductive and oxidative stress: K. Araki, et al.; J. Proteome Res. 15, 2548 (2016), Application(s): Western blot, Abstract
The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis: J. Zhou, et al.; J. Clin. Invest. 125, 4391 (2015), Application(s): Western blot, Abstract — Full Text
∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis: S. Pankow, et al.; Nature. 528, 510 (2015), Application(s): Immunofluorescence / Reactant(s): Human, Abstract — Full Text
Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart: S. Sen, et al.; J. Am. Heart. Assoc. 2, e004796 (2013), Application(s): Western blot, Abstract — Full Text

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ERp72 polyclonal antibody

ADI-SPS-720

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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