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Endothelin A receptor polyclonal antibody

ALX-210-507A

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Endothelins are a family of peptides that are potent vasoconstrictors produced by mammalian vascular endothelial cells. The receptors for the endothelins are found on various tissues including, but not restricted to, lung and intestine.

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This antibody is covered by our Worry-Free Guarantee.

Nitric oxide synthase (endothelial) polyclonal antibody Immunohistochemistry — **Figure:** Immunohistochemical staining of invasive ductal carcinoma (G2) using PAb to Endothelin A Receptor (Prod. No. ALX-210-507A). Expression can be seen in the cytoplasma and in the cell membrane.”””,Endothelin A receptor polyclonal antibody Immunohistochemistry,Endothelin A receptor polyclonal antibody Immunohistochemistry,yes
ALX-210-509,210-509_1.gif,http://static.enzolifesciences.com/fileadmin/files/image/210-509_1.gif,**Figure:** Immunolocalization of endothelial nitric oxide synthase (eNOS; NOS III) in human lung tissue using PAb to eNOS (Prod. No. ALX-210-509).”””””

Product Details

Alternative Name	ETA-receptor
Application	IHC, WB
Application Notes	As this antibody is generated against the cytosolic portion of endothelin A receptor, permeabilization is required for immunochemical analysis. Detects bands of 34-52kDa by Western blot. Does not block the binding of endothelins to the receptor.
Formulation	Liquid. In TRIS-citrate-phosphate, pH 7-8, containing 0.1% sodium azide.
Host	Sheep
Immunogen	Synthetic peptide corresponding to aa 410-422 (Q410EQNHNTERSSHK422) of C-terminal rat ETA-receptor (endothelin A receptor).
Purity Detail	Epitope-affinity purified.
Recommendation Dilutions/Conditions	Immunohistochemistry (paraffin sections, 4µg/ml)Western Blot (10-20µg/ml using ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human, Mouse, Rat
Specificity	Recognizes an epitope on the cytoplasmic side of the ET_A-receptor.
UniProt ID	P26684
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Lipid-soluble Cigarette Smoke Particles Induced Vascular Endothelin Type A Receptor Up-Regulation through Activation of ERK1/2 Signal Pathways: Zhang, Y., Zhang, W., et al.; Basic Clin. Pharmacol. Toxicol. 120, 327 (2017), Abstract
Changes by tacrolimus of the rat aortic proteome: Involvement of endothelin-1: J.J. Zamorano-Leon, et al.; Transpl. Immunol. 26, 191 (2012), Application(s): Western blot, Abstract
Expression patterns of endothelin‐1 and its receptors in colorectal cancer: P. Liakou, et al.; J. Surg. Oncol. 105, 643 (2012), Abstract
Expression of endothelin receptor subtypes in bronchial tumors: S. Blouquit-Laye, et al.; Oncol. Rep. 23, 457 (2010), Application(s): Immunohistochemistry on paraffin-embedded tissue sections, Abstract
Relationship between endothelin-1 and interleukin-1beta in inflamed periodontal tissues: T. Rikumaru, et al.; Biomed. Res. 30, 349 (2009), Application(s): Western blot, Abstract
Selective ETAR antagonist atrasentan inhibits hypoxia-induced breast cancer cell invasion: M. Smollich, et al.; Breast Cancer Res. Treat. 108, 175 (2008), Abstract
Endothelin-3 growth factor levels decreased in cervical cancer compared with normal cervical epithelial cells: D.J. Sun, et al.; Hum. Pathol. 38, 1047 (2007), Application(s): Immunohistochemistry on paraffin-embedded tissue sections, Abstract
Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: a tissue microarray analysis: E. Hermann, et al.; Oncol. Rep. 17, 275 (2007), Application(s): Immunohistochemistry on paraffin-embedded tissue sections, Abstract
Beta2-adrenoceptor agonist modulates endothelin-1 receptors in human isolated bronchi: C. Faisy, et al.; Am. J. Respir. Cell. Mol. Biol. 34, 410 (2006), Application(s): Immunohistochemistry on paraffin-embedded tissue sections, Abstract
Inhibition of carotis venous bypass graft disease by intraoperative nucleic acid-based therapy in rabbits: B. Kusch, et al.; Thorac. Cardiovasc. Surg. 54, 388 (2006), Application(s): Immunohistochemistry on paraffin-embedded tissue sections, Abstract

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Endothelin A receptor polyclonal antibody

ALX-210-507A

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Datasheet, Manuals, SDS & CofA

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