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eIF2 α polyclonal antibody

ADI-KAP-CP130

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EIF-2α, also known as eukaryotic translation initiation factor 2α, promotes the binding of the initiator tRNA to the 40S ribosomal subunits and controls translational rates via phosphorylation/dephosphorylation mechanisms. The double-stranded RNA (dsRNA)-activated protein kinase (PKR) provides an important control in the regulation of protein synthesis initiation through the phosphorylation of eIF-2α. Phosphorylated eIF-2α inhibits cell growth and induces apoptosis. Phosphorylation of eIF-2α occurs under a variety of conditions including viral infection, apoptosis, nutrient deprivation, heme-deprivation, and certain stresses. EIF-2 exists as a heterotrimeric protein composed of 3 nonidentical subunits, alpha (36 kDa), beta (38 kDa), and gamma (52 kDa).

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This antibody is covered by our Worry-Free Guarantee.

eIF2 α polyclonal antibody Immunohistochemistry — IHC Analysis: Human vessel tissue stained with eIF2 α, pAb at 10µg/ml.

Product Details

Alternative Name	Eukaryotic translation initiation factor 2 subunit α
Application	ICC, IHC (PS), WB
Application Notes	Detects a band of ~36kDa by Western blot.
Formulation	Liquid. In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
Host	Rabbit
Immunogen	Synthetic peptide corresponding to a portion of rat eIF2-α.
Purity Detail	Immunoaffinity purified.
Recommendation Dilutions/Conditions	Western Blot (1µg/ml, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from rabbit serum.
Species Reactivity	Bovine, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep
UniProt ID	P68101
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Queuosine-tRNA promotes sex-dependent learning and memory formation by maintaining codon-biased translation elongation speed: Cirzi, C., Dyckow, J., et al.; EMBO J. 42, e112507 (2023), Abstract
PERK prevents hepatic lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway: D.H. Lee, et al.; Redox Biol. 1016, 102235 (2022), Abstract
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models: Lourenco, M. V., Frozza, R. L., et al.; Nat. Med. 25, 165 (2019), Abstract
Queuosine-modified tRNAs confer nutritional control of protein translation: Tuorto, F., Legrand, C., et al.; EMBO J. 37, (2018), Abstract
Musashi-1 maintains blood-testis barrier structure during spermatogenesis and regulates stress granule formation upon heat stress: S. ErLin, et al.; Mol. Biol. Cell 26, 1947 (2015), Application(s): Western Blotting, Abstract — Full Text
Arenavirus infection induces discrete cytosolic structures for RNA replication.: Baird, N. L., York, J., et al.; J. Virol. 86, 11301 (2012), Reactant(s): Green monkey, Abstract
Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation: L. Brown, et al.; Am. J. Physiol. Endocrinol. Metab. 297, E638 (2009), Application(s): WB using sheep tissue, Abstract
Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules: P. Anderson, et al.; Mol. Biol. Cell 13, 195 (2002), Application(s): ICC, WB using human samples, Abstract
PERK mediates cell-cycle exit during the mammalian unfolded protein response: J.A. Diehl, et al.; PNAS 97, 12625 (2000), Application(s): WB using mouse samples, Abstract

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eIF2 α polyclonal antibody

ADI-KAP-CP130

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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