Dynasore

ALX-270-502

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GTPase inhibitor

Small molecule GTPase inhibitor targeting Dynamin-1, Dynamin-2 and Drp1 (mitochondrial Dynamin). Noncompetitive inhibitor of Dynamin GTPase activity. Blocks Dynamin-dependent endocytosis in cells (including neurons). Fast acting (seconds). Strong, dose dependent block of the traffic and accumulation of transferrin with 80µM dynasore (IC₅₀ = 15µM). Has also been shown to block human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.

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Product Details

Appearance	Off-white solid.
CAS	304448-55-3
Couple Target	Dynamin, GTPase
Couple Type	Inhibitor
Formula	C₁₈H₁₄N₂O₄
MW	322.3
Purity	≥98% (HPLC, TLC)
Solubility	Soluble in 100% ethanol (1mg/ml) or DMSO (10mg/ml); insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling	Protect from light. Keep under inert gas.
Short Term Storage	-20°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

GM101 in Combination with Histone Deacetylase Inhibitor Enhances Anti-Tumor Effects in Desmoplastic Microenvironment: H.G. Chang, et al.; Cells 10, 2811 (2021), Application(s): U343 cells treatment, Abstract — Full Text
Lysosomal dysfunction and autophagy blockade contribute to MDMA-induced neurotoxicity in SH-SY5Y neuroblastoma cells: I.H. Li, et al.; Chem. Res. Toxicol. 33, 903 (2020), Abstract
The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation: K. Skouloudaki, et al.; PLoS Genet. 15, e1007852 (2019), Abstract — Full Text
Bacterial LPX motif-harboring virulence factors constitute a species-spanning family of cell-penetrating effectors: S. Norkowski, et al.; Cell. Mol. Life Sci. 75, 2273 (2018), Abstract
Bacterium-Derived Cell-Penetrating Peptides Deliver Gentamicin To Kill Intracellular Pathogens: Gomarasca, M., F C Martins, T., et al.; Antimicrob. Agents Chemother. 61, (2017), Abstract
The Bif-1-Dynamin 2 membrane fission machinery regulates Atg9-containing vesicle generation at the Rab11-positive reservoirs: Takahashi, Y., Tsotakos, N., et al.; Oncotarget 7, 20855 (2016), Abstract
PKCε-mediated c-Met endosomal processing directs fluctuant c-Met-JNK-paxillin signaling for tumor progression of HepG2: C.T. Hu, et al.; Cell. Signal. 27, 1544 (2015), Application(s): Cell Culture, Abstract
c-jun N-terminal kinase attenuates TNFα signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells: H. Choi, et al.; Free Radic. Biol. Med. 86, 219 (2015), Abstract
Dissecting virus entry: replication-independent analysis of virus binding, internalization, and penetration using minimal complementation of β-galactosidase: Burkard, C., Bloyet, L. M., et al.; PLoS One 9, e101762 (2014), Abstract
CCR5 conformations are dynamic and modulated by localization, trafficking and G protein association: Flegler, A. J., Cianci, G. C., et al.; PLoS One 9, e89056 (2014), Abstract

Last modified: May 29, 2024

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Dynasore

ALX-270-502

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