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DL-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol

BML-SL210

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Glucosylceramide synthetase inhibitor

Blocks glucosylation of ceramide by inhibiting UDP-glucose:ceramide glucosyltransferase (glucosylceramide synthetase). Inhibits the expression of cell surface glycolipid antigens and inhibits the growth of cultured rabbit skin fibroblasts. Possesses antitumor activity and inhibits Lewis lung carcinoma cell metastasis in vitro. Useful tool for studying the effects of cellular glycosphingolipid depletion. Enhances the apoptotic response to ionizing radiation by enhancing the ceramide signal.

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Product Details

Alternative Name	D,L-threo-PDMP . hydrochloride, DL-PDMP
Appearance	White to off-white solid.
CAS	80938-69-8
Couple Target	Glucosylceramide synthetase
Couple Type	Inhibitor
Formula	C₂₃H₃₈N₂O₃ . HCl
MW	390.6 . 36.5
Purity	≥98% (TLC)
Solubility	25mg/ml soluble in 100% ethanol, DMSO or water (50°C, vortex or sonicate).
Technical Info / Product Notes	Note: Product is not sterile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for up to 1 year after receipt when stored at -20°C. Solutions are stable for up to 3 months when stored at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids: J. Liu, et al.; Nat. Commun. 14, 465 (2023), Abstract
Probing Physical Properties of the Cellular Membrane in Senescent Cells by Fluorescence Imaging: J.H. Wi, et al.; J. Phys. Chem. B 125, 10182 (2021), Abstract
C16:0 ceramide effect on melanoma malignant behavior and glycolysis depends on its intracellular or exogenous location: Liu, R., Cao, K., et al.; Am. J. Transl. Res. 12, 1123 (2020), Abstract
PDMP induces rapid changes in vacuole morphology in Arabidopsis root cells: Krüger, F., Krebs, M., et al.; J. Exp. Bot. 64, 529 (2013), Abstract
Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing: C. Rodriguez-Lafrasse, et al.; Int. J. Cancer 101, 589 (2002), Abstract
Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases: C.S. Rani, et al.; J. Biol. Chem. 270, 2859 (1995), Abstract — Full Text
Effects of a sphingolipid synthesis inhibitor on membrane transport through the secretory pathway: A.G. Rosenwald; Biochemistry 31, 3581 (1992), Abstract
Use of PDMP for the Study of Glycosphingolipid Functions: N.S. Radin and J.-I. Inokuchi; Trends Glycosci. Glycotechnol. 3, 200 (1991), Full Text
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor: G.S. Shukla, et al.; Biochim. Biophys. Acta 1083, 101 (1991), Abstract
Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action: J.-I. Inokuchi, et al.; Cancer Res. 50, 6731 (1990), Abstract

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Last modified: May 29, 2024

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DL-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol

BML-SL210

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