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NADPH oxidase inhibitor
Binds strongly to flavoproteins and is thus a powerful and specific inhibitor of several important enzymes, including nitric oxide synthase (NOS), NADPH-ubiquinone oxidoreductase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Nitric oxide synthase, which shows significant homology with cytochrome P450 reductase, has been shown to be irreversibly inhibited by this compound in cultured peritoneal macrophages (IC50=30nM).
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Product Details
| Alternative Name |
DPI chloride, Dibenziodolium chloride |
|---|---|
| Appearance |
White to off-white solid. |
| CAS |
4673-26-1 |
| Couple Target |
Cytochrome P450 reductase, NOS |
| Couple Type |
Inhibitor |
| Formula |
C12H8I . Cl |
| Identity |
Determined by 1H-NMR and MS. |
| MW |
314.5 |
| Purity |
≥98% (HPLC) |
| Solubility |
Soluble in DMSO (warm) (5mg/ml). |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Leptin impairs the therapeutic efficacy of adipose-derived mesenchymal stem cells by inducing apoptosis through NLRP3 inflammasomes activation: T.K. Nguyen, et al.; Biochem. Pharmacol. 236, 116868 (2025), Abstract
- Carbon Monoxide Releasing Molecule-3 Enhances Heme Oxygenase-1 Induction via ROS-Dependent FoxO1 and Nrf2 in Brain Astrocytes: C. C. Lin, et al.; Oxid. Med. Cell. Longev. 2021, 5521196 (2021), Abstract
- Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis: Bedient, L., Pokharel, S. M., et al.; Viruses 12, (2020), Abstract
- Neutrophils Discriminate between Lipopolysaccharides of Different Bacterial Sources and Selectively Release Neutrophil Extracellular Traps: E. Pieterse, et al.; Front. Immunol. 7, 484 (2016), Abstract — Full Text
- Globular adiponectin attenuates LPS-induced reactive oxygen species production in HepG2 cells via FoxO3A and HO-1 signaling: A. Shrestha & P.H. Park; Life Sci. 148, 71 (2016), Application(s): Cell culture, Abstract
- The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor: Suzuki, H., Hatano, N., et al.; Am. J. Physiol. Cell Physiol. 307, C384 (2014), Abstract
- Astragaloside IV attenuates glycated albumin-induced epithelial-to-mesenchymal transition by inhibiting oxidative stress in renal proximal tubular cells: Qi, W., Niu, J., et al.; Cell Stress Chaperones 19, 105 (2014), Abstract
- NADPH oxidase-driven phagocyte recruitment controls Candida albicans filamentous growth and prevents mortality: Brothers, K. M., Gratacap, R. L., et al.; PLoS Pathog. 9, e1003634 (2013), Abstract
- Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells: Efimova, O., Szankasi, P., et al.; PLoS One 6, e16013 (2011), Abstract
- Extracellular-superoxide dismutase expression during monocytic differentiation of U937 cells: T. Kamiya, et al.; J. Cell. Biochem. 112, 244 (2011), Application(s): Treatment of U937 cells in culture, Abstract
- Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration: Venkatesan, B., Valente, A. J., et al.; Am. J. Physiol. Heart Circ. Physiol. 297, H874 (2009), Abstract
- Selective and irreversible cell cycle inhibition by diphenyleneiodonium: R.M. Scaife; Mol. Cancer Ther. 4, 876 (2005), Abstract
- Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium: A. Balcerczyk, et al.; Biochem. Pharmacol. 69, 1263 (2005), Abstract
- G2 cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodonium: R.M. Scaife; Mol. Cancer Ther. 3, 1229 (2004), Abstract
- Preferential inhibition of the plasma membrane NADH oxidase (NOX) activity by diphenyleneiodonium chloride with NADPH as donor: D.J. Morre; Antioxid. Redox Signal. 4, 207 (2002), Abstract
- Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat: H. Kono, et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 280, G1005 (2001), Abstract
- Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species: A.F. Mendes, et al.; Mediators Inflamm. 10, 209 (2001), Abstract
- Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications: D.G. Tew; Biochemistry 32, 10209 (1993), Abstract
- Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs: D.J. Stuehr, et al.; FASEB J. 5, 98 (1991), Abstract
- Purification and some properties of the 45 kDa diphenylene iodonium- binding flavoprotein of neutrophil NADPH oxidase: C.M. Yea, et al.; Biochem. J. 265, 95 (1990), Abstract
- Indications to an NADPH oxidase as a possible pO2 sensor in the rat carotid body: H. Acker, et al.; FEBS Lett. 256, 75 (1989), Abstract
- The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages: J.T. Hancock & O.T.G. Jones; Biochem. J. 242, 103 (1987), Abstract
- The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase.: A.R. Cross & O.T. Jones; Biochem. J. 237, 111 (1986), Abstract
- Specific labelling of a constituent polypeptide of bovine heart mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone reductase by the inhibitor diphenyleneiodonium: C.I. Ragan & D.P. Bloxham; Biochem. J. 163, 605 (1977), Abstract
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