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Phospholipase inhibitor
Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC). Has been used to study the coupling of phosphatidylcholine-specific phospholipase C with sphingomyelinase. Shows antitumor and antiviral activity. Inhibits basement membrane collagen synthesis, which is the last step in the development of a new blood vessel. Inhibits induction of nitric oxide synthases (NOS). Induces apoptosis. It indirectly inhibits phorbol ester stimulated PLD activity.
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Product Details
| Alternative Name |
Tricyclodecan-9-yl xanthogenate . K |
|---|---|
| Appearance |
Off-white solid. |
| CAS |
83373-60-8 |
| Couple Target |
Phospholipase, PLC |
| Couple Type |
Inhibitor |
| Formula |
C11H15OS2 . K |
| MW |
266.5 |
| Purity |
≥98% (TLC) |
| Solubility |
Soluble in water (25mg/ml). |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. We recommend to prepare fresh solutions each day. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Improved plaque assay identifies a novel anti-Chlamydia ceramide derivative with altered intracellular localization: Banhart, S., Saied, E. M., et al.; Antimicrob. Agents Chemother. 58, 5537 (2014), Abstract
- CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation: Pupovac, A., Stokes, L., et al.; Purinergic Signal. 9, 609 (2013), Abstract
- Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans: Qureshi, A., Subathra, M., et al.; PLoS One 5, e15587 (2011), Abstract
- D609 blocks cell survival and induces apoptosis in neural stem cells: N. Wang, et al.; Bioorg. Med. Chem. Lett. 16, 4780 (2006), Abstract
- Two distinct Fas-activated signaling pathways revealed by an antitumor drug D609: L. Zhang, et al.; Oncogene 24, 2954 (2005), Abstract
- Protection against amyloid beta-peptide (1-42)-induced loss of phospholipid asymmetry in synaptosomal membranes by tricyclodecan-9-xanthogenate (D609) and ferulic acid ethyl ester: implications for Alzheimer´s disease: H. Mohmmad Abdul & D.A. Butterfield; Biochim. Biophys. Acta 1741, 140 (2005), Abstract
- Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells: A. Meng, et al.; Exp. Cell Res. 292, 385 (2004), Abstract
- Protective effect of the xanthate, D609, on Alzheimer´s amyloid beta-peptide (1-42)-induced oxidative stress in primary neuronal cells: R. Sultana, et al.; Free Radic. Res. 38, 449 (2004), Abstract
- Synthesis and phospholipase C inhibitory activity of D609 diastereomers: A. Gonzalez-Roura, et al.; Lipids 37, 401 (2002), Abstract
- D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant: D. Zhou, et al.; J. Pharmacol. Exp. Ther. 298, 103 (2001), Abstract — Full Text
- D609-sensitive tyrosine phosphorylation is involved in Fas-mediated phospholipase D activation: J.G. Kim, et al.; Exp. Mol. Med. 33, 303 (2001), Abstract — Full Text
- D609-phosphatidylcholine-specific phospholipase C inhibitor attenuates thapsigargin-induced sodium influx in human lymphocytes: J.R. Nofer, et al.; Cell Signal. 12, 289 (2000), Abstract
- Phosphatidylcholine-specific phospholipase inhibitor D609 differentially affects MAP kinases and immediate-early genes in PC12 cells: P.J. Kahle, et al.; Cell Signal. 10, 321 (1998), Abstract
- Stimulation of DNA synthesis in untransformed cells by the antiviral and antitumoral compound tricyclodecan-9-yl-xanthogenate (D609): Z. Kiss, et al.; Biochem. Pharmacol. 55, 915 (1998), Abstract
- A phosphatidylcholine phospholipase C inhibitor, D609, blocks interleukin-3 (IL-3)-induced bcl-2 expression but not c-myc expression in human IL-3-dependent cells: R.A. Mufson, et al.; Exp. Cell Res. 240, 228 (1998), Abstract
- Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis: D.C. Hooper, et al.; PNAS 94, 2528 (1997), Abstract — Full Text
- The antiviral xanthate compound D609 inhibits herpes simplex virus type 1 replication and protein phosphorylation: D.G. Walro & K.S. Rosenthal; Antiviral Res. 36, 63 (1997), Abstract
- Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609: M.I. Porn-Ares, et al.; Exp. Cell Res. 235, 48 (1997), Abstract
- Compound D609 inhibits phorbol ester-stimulated phospholipase D activity and phospholipase C-mediated phosphatidylethanolamine hydrolysis: Z. Kiss & M. Tomono; Biochim. Biophys. Acta 1259, 105 (1995), Abstract
- Inhibitors of basement membrane collagen synthesis prevent endothelial cell alignment in matrigel in vitro and angiogenesis in vivo: G.C. Haralabopoulos, et al.; Lab. Invest. 71, 575 (1994), Abstract
- Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609): K. Tschaikowsky, et al.; Br. J. Pharmacol. 113, 664 (1994), Abstract
- Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction: H. Cai, et al.; Mol. Cell Biol. 13, 7645 (1993), Abstract
- TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced acidic” sphingomyelin breakdown”””: S. Schütze, et al.; Cell 71, 765 (1992), Abstract
- Interruption of TPA-induced signals by an antiviral and antitumoral xanthate compound: inhibition of a phospholipase C-type reaction: K. Muller-Decker; BBRC 162, 198 (1989), Abstract
- Interruption of growth signal transduction by an antiviral and antitumoral xanthate compound: K. Muller-Decker, et al.; Exp. Cell. Res. 177, 295 (1988), Abstract
- DNA and RNA virus species are inhibited by xanthates, a class of antiviral compounds with unique properties: G. Sauer, et al.; PNAS 81, 3263 (1984), Abstract
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