CP-55,940

BML-CR102

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Cannabinoid receptor ligand

Cannabinoid CB₁ and CB₂ agonist which is more potent than δ9-THC. K_d’s for cloned/transfected CB₁ and CB₂: 2.6 & 3.7 nM. Has been reported to induce the immediate early gene Krox-24 in corpus striatum and cultured astrocytes. Stimulates proliferation of stimulated B-cells at low nM concentrations.

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Product Details

Appearance	White solid.
CAS	83002-04-4
Couple Target	Cannabinoid receptor
Couple Type	Ligand
Formula	C₂₄H₄₀O₃
MW	376.6
Purity	≥96% (HPLC)
Solubility	Soluble in DMSO (4mg/ml) or ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells: Y. Waksman et al.; J. Pharmacol. Exp. Ther. 288, 1357 (1999), Abstract
Comparative receptor binding analyses of cannabinoid agonists and antagonists: B.F. Thomas et al.; J. Pharmacol. Exp. Ther. 285, 285 (1998), Abstract
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors: C.C. Felder et al.; Mol. Pharmacol. 48, 443 (1995), Abstract
Induction of the Krox 24 transcription factor in striosomes by a cannabinoid agonist: M. Glass & M. Dragunow; Neuroreport 6, 241 (1995), Abstract
Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells: M. Bouaboula et al.; J. Biol. Chem. 270, 13973 (1995), Abstract
Cannabinoids enhance human B-cell growth at low nanomolar concentrations: J.M. Derocq et al.; FEBS Lett. 369, 177 (1995), Abstract
Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats: J.L. Wiley et al.; Neuropharmacology 34, 669 (1995), Abstract

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Last modified: October 22, 2024

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CP-55,940

BML-CR102

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