Clozapine

BML-D107

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Dopamine receptor and serotonin receptor antagonist

Dopamine D₄ and D₂ receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (K_i<20nM). Atypical neuroleptic agent. Antagonist at 5HT_2A, 5HT_2C, 5HT₃, 5HT₆ and 5HT₇ receptors.

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Product Details

Alternative Name	8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e]-[1,4]diazepine
Appearance	Yellow crystalline powder.
CAS	5786-21-0
Couple Target	Dopamine receptor, Serotonin receptor
Couple Type	Ligand
Formula	C₁₈H₁₉ClN₄
Identity	Determined by IR.
MI	14: 2423
MW	326.8
Purity	≥99% (HPLC)
RTECS	HP1750000
Solubility	Soluble in DMSO (30mg/ml) or dilute aqueous acid.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways: J. Midkiff, et al.; PLoS One 6, e25395 (2011), Abstract — Full Text
Interaction of clozapine with the histamine H3 receptor in rat brain: A.A. Rodrigues, et al.; Br. J. Pharmacol. 114, 1523 (1995), Abstract
D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs: B.L. Roth, et al.; Psychopharmacology 120, 365 (1995), Abstract
Role of serotonin in the action of atypical antipsychotic drugs: H.Y. Meltzer; Clin. Neurosci. 3, 64 (1995), Abstract
5-HT1C receptor-mediated phosphoinositide hydrolysis in the rat choroid plexus after chronic treatment with clozapine: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 255, 91 (1994), Abstract
Clozapine is a potent and selective muscarinic M4 receptor agonist: S.H. Zorn, et al.; Eur. J. Pharmacol. 269, R1 (1994), Abstract
Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 245, 179 (1993), Abstract
The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine: B.A. Ellenbroek, et al.; Eur. J. Pharmacol. 196, 103 (1991), Abstract
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine: H.H. Van Tol, et al.; Nature 350, 610 (1991), Abstract
Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites: H. Canton, et al.; Eur. J. Pharmacol. 191, 93 (1990), Abstract

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Clozapine

BML-D107

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