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Chlorpromazine . hydrochloride

ALX-270-171

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Antipsychotic working on a variety of receptors in the CNS

Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D₂antagonist. H₁antagonist. Inhibits TNF-α production. Potent PLA₂inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.

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Product Details

Alternative Name	2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
Appearance	White to off-white powder.
CAS	69-09-0
Couple Target	Acetylcholine receptor, Adrenergic receptor, Calmodulin, Dopamine receptor, Histamine receptor, PDE, PLA, Serotonin receptor
Couple Type	Inhibitor
Formula	C₁₇H₁₉ClN₂S . HCl
MI	14: 2185
MW	355.3
Purity	≥98% (UHPLC)
RTECS	SO1750000
Solubility	Soluble in 100% ethanol, methanol or water (50mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
Handling	Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature – Dangerous Good

Regulatory Status	RUO – Research Use Only

Magnetic colloidal nanoformulations to remotely trigger mechanotransduction for osteogenic differentiation: M. Estévez, et al.; J. Colloid Interface Sci. 15, 664 (2024), Abstract
GM101 in Combination with Histone Deacetylase Inhibitor Enhances Anti-Tumor Effects in Desmoplastic Microenvironment: H.G. Chang, et al.; Cells 10, 2811 (2021), Application(s): U343 cells treatment, Abstract — Full Text
Effects of Ipriflavone-Loaded Mesoporous Nanospheres on theDifferentiation of Endothelial Progenitor Cells and TheirModulation by Macrophages: L. Casarrubios, et al.; Nanomaterials 11, 1102 (2021), Abstract
Pseudovirus mimics cell entry and trafficking of the human polyomavirus JCPyV: Gee, G. V., O’Hara, B. A., et al.; Virus Res. 178, 281 (2013), Abstract
Low-pH triggering of human metapneumovirus fusion: essential residues and importance in entry: Schowalter, R. M., Chang, A., et al.; J. Virol. 83, 1511 (2009), Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine: S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys. 430, 170 (2004), Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase: A. Boveris, et al.; Methods Enzymol. 359, 328 (2002), Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice: M.G. Netea, et al.; J. Infect. Dis. 171, 393 (1995), Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice: H. Yamamoto; Toxicol. Lett. 66, 73 (1993), Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge: M. Palacios, et al.; BBRC 196, 280 (1993), Abstract

Last modified: May 29, 2024

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Chlorpromazine . hydrochloride

ALX-270-171

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Handling & Storage

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