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Chelerythrine chloride

BML-EI225

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PKC inhibitor

Reported to be a potent and selective inhibitor of protein kinase C (IC₅₀=0.66µM). Although chelerythrine has numerous documented biological effects, studies have raised serious doubts about the effectiveness of chelerythrine as a PKC inhibitor.

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Product Details

Appearance	Yellow solid.
CAS	3895-92-9
Couple Target	PKC
Couple Type	Inhibitor
Formula	C₂₁H₁₈ClNO₄
MI	14: 2051
MW	383.8
Purity	≥98% (HPLC, TLC)
RTECS	FL9200000
Solubility	Soluble in DMSO, water (2mg/ml warm), 100% ethanol or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Heating to 40-50°C with gentle agitation may support complete solubilization. Further dilute with buffer just prior to use. Stock solutions should be refrigerated or frozen between for storage.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression: A. Bruneau, et al.; Cells 11, 617 (2022), Abstract
Follicle-Stimulating Hormone (FSH)-dependent Regulation of Extracellular Regulated Kinase (ERK) Phosphorylation by the Mitogen-activated Protein (MAP) Kinase Phosphatase MKP3: E.M. Donaubauer, et al.; J. Biol. Chem. 291, 19701 (2016), Application(s): Inhibition of MKP1 in Granulosa Cells, Abstract — Full Text
Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons: Yao, Y., Shao, C., et al.; Neuropharmacology 64, 37 (2013), Abstract
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol. 364, 536 (2006), Abstract
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol. 22, 439 (2006), Abstract
Identification of chelerythrine as an inhibitor of BclXL function: S.L. Chan, et al.; J. Biol. Chem. 278, 20453 (2003), Abstract
Polarized signaling via purinoceptors in normal and cystic fibrosis airway epithelia: Paradiso, A. M., Ribeiro, C. M., et al.; J. Gen. Physiol. 117, 53 (2001), Abstract
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C: W.D. Jarvis, et al.; Cancer Res. 54, 1707 (1994), Abstract
Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans: F.N. Ko, et al.; Biochim. Biophys. Acta 1052, 360 (1990), Abstract
Chelerythrine is a potent and specific inhibitor of protein kinase C: J.M. Herbert, et al.; BBRC 172, 993 (1990), Abstract

Last modified: May 29, 2024

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Chelerythrine chloride

BML-EI225

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Handling & Storage

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