Capsaicin

BML-EI125

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TRPV1 agonist

Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. Exhibits neuroprotective effects in a model of transient global cerebral ischemia. Induces release of substance P from afferent nociceptive specific neurons. Constituent of cayenne pepper. Powerful excitant of peropheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets.

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Product Details

Alternative Name	8-Methyl-N-vanillyl-6-nonenamide
Appearance	White to pale yellow.
CAS	404-86-4
Couple Target	TRP channel
Couple Type	Activator
Formula	C₁₈H₂₇NO₃
MW	305.4
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol, methanol or chloroform. Sparingly soluble in water.
Source	Isolated from Capsicum fruit.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Slick potassium channels limit TRPM3-mediated activation of sensory neurons: Engel, P., Zhou, F., et al.; Front. Pharmacol. 15, 1459735 (2025), Abstract
A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator: E. Manzo, et al.; Cells 450, 450 (2021), Abstract — Full Text
Glucose concentration in culture medium affects mRNA expression of TRPV1 and CB1 receptors and changes capsaicin toxicity in PC12 cells: Mohammadi-Farani, A., Ghazi-Khansari, M., et al.; Iran J. Basic. Med. Sci. 17, 673 (2014), Abstract
Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain: W. Ma & R. Quirion; Expert Opin. Ther. Targets 11, 307 (2007), Abstract
Forty years in capsaicin research for sensory pharmacology and physiology: J. Szolcsanyi; Neuropeptides 38, 377 (2004), Abstract
Capsaicin sensitive-sensory nerves and blood pressure regulation: P. Vaishnava & D.H. Wang; Curr. Med. Chem. Cardiovasc. Hematol. Agents 1, 177 (2003), Abstract
Peppers and pain. The promise of capsaicin: B.M. Fusco & M. Giacovazzo; Drugs 53, 909 (1997), Abstract
Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential: Y.J. Surth & S.S. Lee; Life. Sci. 56, 1845 (1995), Abstract
Topical capsaicin. A review of its pharmacological properties and therapeutic potential in post-herpetic neuralgia, diabetic neuropathy and osteoarthritis: C. Rains & H.M. Bryson; Drugs Aging 7, 317 (1995), Abstract
Capsaicin: identification, nomenclature, and pharmacotherapy: G.A. Cordell & O.E. Araujo et al.; Ann. Pharmacother. 27, 330 (1993), Abstract

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Last modified: May 29, 2024

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Capsaicin

BML-EI125

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