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Calreticulin polyclonal antibody

ADI-SPA-600

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ADI-SPA-600-J — 1 mg

$1,864.00

Calreticulin polyclonal antibody quantity
ADI-SPA-600-D — 50 µg

$219.00

Calreticulin polyclonal antibody quantity
ADI-SPA-600-F — 200 µg

$484.00

Calreticulin polyclonal antibody quantity

Calreticulin (CRT) is a multifunctional, multi-compartmental protein most abundant in the ER lumen. CRT contains the ER-retrieval sequence, KDEL, and has been best characterized as a soluble molecular chaperone of new or misfolded proteins and a Ca2+- binding protein. Both CRT and its membrane bound homolog, Calnexin (CNX) interact with proteins and glycoproteins that have monoglucosylated N-glycans. The CRT/CNX cycle promotes correct folding, inhibits aggregation of folding intermediates, blocks premature oligimerization, regulates ER degradation, and provides quality control by preventing incompletely folded glycoproteins from exiting to the Golgi complex.

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This antibody is covered by our Worry-Free Guarantee.

Calreticulin polyclonal antibody Western blot — Western Blot Analysis of Calreticulin: Lane 1: MWM, Lane 2: HeLa cell lysate, Lane 3: PC-12 cell lysate. Lane 4: 3T3 cell lysate

Product Details

Alternative Name	CALR, CRT
Application	ICC, IHC, IP, WB
Application Notes	Predicted MW of ~63kDa.
Formulation	Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
GenBank ID	AD000092
Host	Rabbit
Immunogen	Synthetic peptide corresponding to the sequence near the C-terminus of human Calreticulin.
Purity Detail	Protein A affinity purified.
Recommendation Dilutions/Conditions	Western Blot (1:1,000, human; 1:500, mouse; ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from rabbit serum.
Species Reactivity	Bovine, Dog, Human, Mouse, Rat
UniProt ID	P27797
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism: Wang, L., Mirabella, V. R., et al.; Mol. Psychiatry 29, 1620 (2024), Abstract
UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins.: Ninagawa, S., Matsuo, M., et al.; Elife 12, (2024), Application(s): WB, Abstract
The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis: Hazari, Y., Urra, H., et al.; bioRxiv , (2023)
ATF6β Deficiency Elicits Anxiety-like Behavior and Hyperactivity Under Stress Conditions.: Tanaka, T., Nguyen, D. T., et al.; Neurochem. Res. 48, 2175 (2023), Application(s): IHC / Reactant(s): Mouse, Abstract
Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1: A. Pierga, et al.; PLoS Biol. 21, e3002337 (2023), Abstract
RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy: J. Zhang, et al.; Nat. Commun. 13, 6007 (2022), Application(s): WB, Abstract
ATF6β deficiency elicits anxiety-like behavior and hyperactivity under stress conditions: Tanaka, T., Nguyen, D. T., et al.; Research Square , (2022), Application(s): IHC / Reactant(s): Mouse
CF Patients’ Airway Epithelium and Sex Contribute to Biosynthesis Defects of Pro-Resolving Lipids.: Shum, M., London, C. M., et al.; Front. Immunol. 13, 915261 (2022), Application(s): ICC-IF / Reactant(s): Human, Abstract
Analyses of the Autism-associated Neuroligin-3 R451C Mutation in Human Neurons Reveals a Gain-of-Function Synaptic Mechanism: Wang, L., Mirabella, V. R., et al.; bioRxiv , (2021)
The N-terminal region of Jaw1 has a role to inhibit the formation of organized smooth endoplasmic reticulum as an intrinsically disordered region.: Sato, H., Rohrer, J., et al.; Sci. Rep. 11, 753 (2021), Application(s): ICC-IF, Abstract