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C8 Ceramide

BML-SL112

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Ceramide-activated protein kinase activator

A biologically active, cell-permeable, but nonphysiologic ceramide analog. It induces phosphorylation of epidermal growth factor receptor on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase and induces apoptosis.

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Product Details

Appearance	White waxy solid.
CAS	74713-59-0
Couple Target	Ceramide-activated protein kinase
Couple Type	Activator
Formula	C₂₆H₅₁NO₃
MW	425.7
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis: Mendelson, K., Pandey, S., et al.; Elife 6, (2017), Abstract
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway: W.D. Jarvis, et al.; PNAS 91, 73 (1994), Abstract
Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta: S. Mathias, et al.; Science 259, 519 (1993), Abstract
Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha: S. Mathias, et al.; PNAS 88, 10009 (1991), Abstract

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C8 Ceramide

BML-SL112

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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