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Buthionine sulfoximine

BML-FR117

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γ-Glutamyl transpeptidase inhibitor

L-Buthionine-sulfoximine (BSO) induces oxidative stress in cells by irreversibly inhibiting γ-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione.

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Product Details

Alternative Name	BSO
Appearance	White solid.
CAS	83730-53-4
Couple Target	gamma-Glutamyl transpeptidase
Couple Type	Inhibitor
Formula	C₈H₁₈N₂O₃S
MW	222.3
Purity	≥97% (TLC)
Solubility	Soluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Mapping glutathione utilization in the developing zebrafish (Danio rerio) embryo: Rastogi, A., Clark, C. W., et al.; Redox Biol. 26, 101235 (2019), Abstract
A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans: B.A. Martinez, et al.; Cell Death Dis. 6, e1908 (2015), Application(s): Cell Culture, Abstract — Full Text
Manganese superoxide dismutase knock-down in 3T3-L1 preadipocytes impairs subsequent adipogenesis: S. Krautbauer, et al.; Mol. Cell. Biochem. 393, 69 (2014), Application(s): Treatment of 3T3-L1 cells in culture, Abstract
Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice: R. H. Schiestl & R. Reliene; Carcinogenesis 27, 240 (2006), Abstract

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Buthionine sulfoximine

BML-FR117

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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