High purity toxin with minimal lot-to-lot variation
- High purity, native protein available as >98% pure
- Minimal lot-to-lot variation ensures reproducible results
- Lyophilized format for extended shelf-life
Native protein.
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Product Details
Alternative Name |
Islet-activating protein, PTX |
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Appearance |
White powder. |
Application Notes |
Antibody capture, ELISA, LINE assay, cytotoxicity studies |
CAS |
70323-44-3 |
Formulation |
Lyophilized. Contains 0.05M sodium phosphate and 0.5M sodium chloride. |
Purity |
≥98% |
Purity Detail |
Purified protein. |
Source |
From Bordetella pertussis, strain NCTC 10739. |
Handling & Storage
Use/Stability |
As indicated on product label or CoA when stored as recommended. This preparation is lyophilized, aseptically packaged and sealed under vacuum. Do not vortex. Store at 4°C prior to and following reconstitution. Do not freeze. This toxin is considered to be biologically active. The lyophilized preparation will remain active for at least one year. The toxin is not completely soluble and the resulting suspension should be made uniform by gentle mixing, not vortexing, prior to withdrawing aliquots. Do not sterile filter. Resuspended toxin should be used within one month. For use with purified G proteins, the toxin must be structurally converted to artificially create a form of the toxin that interacts directly with G proteins. See Kaslow et al. (1987)This product should be used only by technically qualified personnel. Good laboratory technique should be employed: Avoid mouth pipetting; wear gloves and other protective clothing; avoid inhalation; avoid contact with skin or open wounds; thoroughly wash any area of the body that comes in contact with the toxin with soap and water; wash eyes with water for fifteen minutes; exercise care when handling in hypodermic needles to avoid inadvertent intravenous or subcutaneous injection. |
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Long Term Storage |
+4°C |
Shipping |
Ambient Temperature |
Regulatory Status |
RUO – Research Use Only |
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- A Medium Chain Fatty Acid, 6-hydroxyhexanoic acid (6-HHA), Protects Against Obesity and Insulin Resistance: Sebag, S. C., Qian, Q., et al.; bioRxiv , (2023)
- Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis: D.D. Biswas, et al.; J. Neuroinflammation 19, 158 (2022), Abstract
- Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells: Dickhout, A., Kaczor, D. M., et al.; Int. J. Mol. Sci. 22, (2021), Abstract
- Sensitized heat shock protein 27 induces retinal ganglion cells apoptosis in rat glaucoma model: W. Zhao, et al.; Int. J. Ophthalmol. 13, 525 (2020), Abstract — Full Text
- Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence: Alessio, N., Squillaro, T., et al.; Elife 9, (2020), Abstract
- Icariin exerts estrogen-like activity in ameliorating EAE via mediating estrogen receptor β, modulating HPA function and glucocorticoid receptor expression: Z. Wei, et al.; Am. J. Transl. Res. 8, 1910 (2016), Application(s): Cell culture, Abstract — Full Text
- Diabetes Mellitus and Increased Tuberculosis Susceptibility: The Role of Short-Chain Fatty Acids: E. Lachmandas, et al.; J. Diabetes Res. 2016, Article ID 6014631 (2016), Application(s): HDAC activity in PBMCs, Abstract — Full Text
- Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-Stimulated cAMP Signaling in Murine Osteoblasts: S. Choudhary, et al.; J. Biol. Chem. 291, 3882 (2016), Application(s): Cell culture, Abstract — Full Text
- Icariin has synergistic effects with methylprednisolone to ameliorate EAE via modulating HPA function, promoting anti-inflammatory and anti-apoptotic effects: Z. Wei, et al.; Int. J. Clin. Exp. Med. 8, 20199 (2015), Application(s): EAE induction, Abstract — Full Text
- The oxytocin receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via Gαi signaling: S.H. Kim, et al.; Mol. Cell. Endocrinol. 420, 11 (2015), Application(s): Cell culture, Abstract
- Gαi/o-dependent Ca2+ mobilization and Gαq-dependent PKCα regulation of Ca2+-sensing receptor-mediated responses in N18TG2 neuroblastoma cells: J. S. Sesay, et al.; Neurochem. Int. 90, 142 (2015), Application(s): Cell Culture, Abstract
- The Innate Immune Receptor CD14 Mediates Lymphocyte Migration in EAE: R. Halmer, et al.; Cell. Physiol. Biochem. 37, 269 (2015), Application(s): In vivo, in mice, Abstract — Full Text
Related Products
Pertussis toxin (Bordetella pertussis)
BML-G100
Ultra-pure pertussis toxin delivering optimal antigenicity

Alternative Name | Islet-activating protein, PTX, Holotoxin |
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Purity | ≥95% |
Source | From Bordetella pertussis, strain 165. |
Datasheet, Manuals, SDS & CofA
Manuals And Inserts
Certificate of Analysis
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SDS
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