Home Shop Bleomycin sulfate

Bleomycin sulfate

BML-AP302

Datasheet
Manual
SDS
CofA

Already have an account?

Antitumor antibiotic

Antibiotic with anti-cancer and apoptotic properties
Radiomimetic DNA-cleaving agent that produces double and single DNA strand breaks through an oxygen-radical-dependent mechanism
Highly cited

Bleomycin consists in a complex of 11 glycopeptide anti-cancer antibiotics originally isolated from Streptomyces verticillus. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycin has found clinical application in the treatment of a range of tumors. Bleomycin acts by intercalation of DNA and RNA. In the presence of oxygen and metal ions (e.g. copper and iron), Bleomycin forms a pseudo-enzyme that induces DNA cleavage.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	Blenoxane
Appearance	White crystalline solid.
CAS	9041-93-4
Formula	C₅₅H₈₅N₁₇O₂₅S₄
MI	14: 1318
MW	1512.6
Purity	≥98% (HPLC)
RTECS	EC5991990
Solubility	Soluble in 100% methanol or water (20mg/ml).
Source	Isolated from Streptomyces sp.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Deregulated immune cell recruitment orchestrated by c-MET impairs pulmonary inflammation and fibrosis: Barbosa-Matos, C., Borges-Pereira, C., et al.; Respir. Res. 25, 257 (2024), Abstract
Interstitial Macrophages Lead Early Stages of Bleomycin-Induced Lung Fibrosis and Induce Fibroblasts Activation: Libório-Ramos, S., Barbosa-Matos, C., et al.; Cells 12, (2023), Abstract
Skin fibrosis and recovery is dependent on Wnt activation via DPP4: A. Jussila, et al.; J. Invest. Dermatol. 142, 1597 (2022), Abstract
Inhibiting a mRNA motif binding protein that mediates TGF-β1 upregulation of translation attenuates pulmonary fibrosis in mice: Chen, W., Pilling, D., et al.; bioRxiv , (2022)
A Proximity Ligation Method to Detect Proteins Bound to Single-Stranded DNA after DNA End Resection at DNA Double-Strand Breaks: F.C. Fowler & J.K. Tyler; Methods Protoc. 5, 3 (2022), Abstract
Ameliorating Fibrosis in Murine and Human Tissues with END55, an Endostatin-Derived Fusion Protein Made in Plants: L. Mlakar, et al.; Biomedicines 10, 2861 (2022), Abstract
A model of the aged lung epithelium in idiopathic pulmonary fibrosis: H. Shaghaghi, et al.; Aging 13, 16922 (2021), Abstract — Full Text
Discovery of the S1P2 antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a preclinical candidate for the treatment of idiopathic pulmonary fibrosis: O. Mammoliti, et al.; J. Med. Chem. 64, 6037 (2021), Abstract
Adipocyte lipolysis abrogates skin fibrosis in a Wnt/DPP4-dependent manner: Jussila, A., Caves, E., et al.; bioRxiv , (2021)
Impaired HSF1 transactivation drives proteostasis collapse and senescent phenotype of IPF lung fibroblast: Cuevas-Mora, K., Roque, W., et al.; bioRxiv , (2020)