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BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes and belongs structurally to the TNF receptor family. BCMA associates with BAFF, APRIL, TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-κB, Elk-1, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase. BCMA plays an important role in B cell development, function and regulation.
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Figure: Immunostaining of HEK 293 cells transfected with a human BCMA expression plasmid (left panel), or mock transfected (right panel). Method: 3 days after transfection of cells with the indicated constructs, cells were fixed with acetone or 4% formaldehyde for 5 min. at room temperature. Slides were blocked with normal IgG, and incubated for 1 hour with 5µg/ml MAb to BCMA (human) (Vicky-1) (Prod. No. ALX-804-151) in 1% BSA in 1x PBS. After washes in PBS, samples were incubated with the secondary antibody for 1 hour, washed in PBS and revealed with StreptABComplex/HRP (Vector) and AEC.
Figure: Detection of endogenous human BCMA with MAb to BCMA (human) (Vicky-1) (Prod. No. ALX-804-151).Method: U266 cells (2×105) were incubated on ice for 30 min. with 0.2µg of MAb to BCMA (human) (Vicky-1) or an isotype control in 25µl FACS buffer (PBS, 5% fetal calf serum, 0.02% azide). The primary antibody was revealed with PAb to Rat IgG (R-PE) and then analyzed by flow cytometry.
Western blot analysis of BCMA (human) mAb (Vicky-1) (Prod. No. ALX-804-151): Lane 1: MW marker, Lane 2: BCMA (h):Fc (h) (recombinant) (Prod. No. ALX-522-026).
| Regulatory Status |
RUO – Research Use Only |
|---|
Related Products
| Alternative Name | TNFRSF 17, B cell maturation protein, CD269 |
|---|---|
| Purity | ≥95% (SDS-PAGE) |
| Source | Produced in HEK 293 cells. The extracellular domain of human BCMA (aa 2-54) is fused at the C-terminus to the Fc portion of human IgG1. |
| Alternative Name | B cell maturation protein, TNFRSF 17, CD269 |
|---|---|
| Application | Flow Cytometry |
| Host | Rat |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Alternative Name | B cell maturation protein, TNFRSF 17, CD269 |
|---|---|
| Application | Flow Cytometry |
| Host | Rat |
| Isotype | IgG1 |
| Species Reactivity | Human |