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PKC activator
BAPTA is a Ca2+ chelator with 105-fold greater affinity for Ca2+ than for Mg2+. BAPTA-AM is a cell-permeable derivative which is widely used as an intracellular calcium sponge. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
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Product Details
| Alternative Name |
1,2-bis-(o-Aminophenoxy)-ethane-N,N,N’,N’-tetraacetic acid, tetraacetoxymethyl ester |
|---|---|
| Appearance |
White to off-white powder. |
| CAS |
126150-97-8 |
| Couple Target |
PKC |
| Couple Type |
Activator |
| Formula |
C34H40N2O18 |
| Identity |
Determined by NMR. |
| MW |
764.7 |
| Purity |
≥90% (HPLC) |
| Solubility |
Soluble in DMSO (25mg/ml), dimethyl formamide (25mg/ml) or 100% ethanol (5mg/ml, warm) |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- SARS-CoV-2 causes secretory diarrhea with an enterotoxin-like mechanism, which is reduced by diosmectite: M. Poeta, et al.; Heliyon 8, e10246 (2022), Abstract
- Platelets Fuel the Inflammasome Activation of Innate Immune Cells: Rolfes, V., Ribeiro, L. S., et al.; Cell Rep. 31, 107615 (2020), Abstract
- Chlamydia pneumoniae infection-induced endoplasmic reticulum stress causes fatty acid-binding protein 4 secretion in murine adipocytes: Walenna, N. F., Kurihara, Y., et al.; J. Biol. Chem. 295, 2713 (2020), Abstract
- Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR: Deng, M., Guo, H., et al.; J. Exp. Med. 216, 2838 (2019), Abstract
- Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation: N.N.T. Nguyen, et al.; Sci. Rep. 8, 15486 (2018), Abstract — Full Text
- Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation: Lapaquette, P., Fritah, S., et al.; Elife 6, (2017), Abstract
- NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes: Freeman, L., Guo, H., et al.; J. Exp. Med. 214, 1351 (2017), Abstract
- AMP-activated Kinase (AMPK) Promotes Innate Immunity and Antiviral Defense through Modulation of Stimulator of Interferon Genes (STING) Signaling: Prantner, D., Perkins, D. J., et al.; J. Biol. Chem. 292, 292 (2017), Abstract
- Cadmium overkill: autophagy, apoptosis and necrosis signalling in endothelial cells exposed to cadmium: B. Messner, et al.; Cell Mol. Life Sci. 73, 1699 (2016), Application(s): Sensitive intracellular Ca2+ chelator, Abstract — Full Text
- Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation: C.S. Breton, et al.; Biochimie 116, 141 (2015), Application(s): Cell Culture, Abstract
- Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl: D. Manganaro, et al.; Biochim. Biophys. Acta 1853, 1879 (2015), Application(s): Cell Culture, Abstract
- From blue light to clock genes in zebrafish ZEM-2S cells: Ramos, B. C., Moraes, M. N., et al.; PLoS One 9, e106252 (2014), Abstract
- VEGF-induced retinal angiogenic signaling is critically dependent on Ca²⁺ signaling by Ca²⁺/calmodulin-dependent protein kinase II: Banumathi, E., O’Connor, A., et al.; Invest. Ophthalmol. Vis. Sci. 52, 3103 (2011), Abstract
- Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death: Blenn, C., Wyrsch, P., et al.; Cell. Mol. Life Sci. 68, 1455 (2011), Abstract
- Activation of autophagy of aggregation-prone ubiquitinated proteins by timosaponin A-III: Lok, C. N., Sy, L. K., et al.; J. Biol. Chem. 286, 31684 (2011), Abstract
- Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells: T. Bouschet et al.; J. Biol. Chem. 278, 4778 (2003), Abstract
- Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin: S. Jiang et al.; Exp. Cell Res. 212, 84 (1994), Abstract
- Intracellular calcium chelator, BAPTA-AM, prevents cocaine-induced ventricular fibrillation: G.E. Billman; Am. J. Physiol. 265, H1529 (1993), Abstract
- BAPTA induces a decrease of intracellular free calcium and a translocation and inactivation of protein kinase C in macrophages: P. Dieter et al.; Biol. Chem. Hoppe Seyler 374, 171 (1993), Abstract
- Role of calcium ion in induction of apoptosis by etoposide in human leukemia HL-60 cells: A. Yoshida et al.; Biochem. Biophys. Res. Commun. 196, 927 (1993), Abstract
- Cytosolic calcium as a second messenger for collagen-induced plsatelet responses: J.B. Smith et al.; Biochem. J. 288, 925 (1992), Abstract
- The effect of temperature and ionic strength on the apparent Ca-affinity of EGTA and the analogous Ca-chelators BAPTA and dibromo-BAPTA: S.M. Harrison & D.M. Bers; Biochim. Biophys. Acta 925, 133 (1987), Abstract
- Physiological [Ca2+]i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator: R.Y. Tsien et al.; Nature 298, 478 (1982), Abstract
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