Antipain

ALX-260-093

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Papain inhibitor

Inhibits papain and trypsin and to a small extent plasmin. Antipain is more specific for papain and trypsin than is leupeptin (Prod. No. ALX-260-009). The inhibitory potency of antipain is 100-fold higher than that of elastatinal. Acts by forming a hemiacetal adduct between its aldehyde group and the active serine of the proteinase.

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Product Details

Activity	Inhibitory Activity ≥30 U/mg (Trypsin, L-BAPA)
Alternative Name	[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal . 2HCl
Appearance	White to off-white powder.
CAS	37682-72-7
Couple Target	Papain
Couple Type	Inhibitor
Formula	C₂₇H₄₄N₁₀O₆ . 2HCl
MW	604.7 . 72.9
Purity	≥97% (HPLC)
Sequence	[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal
Solubility	Soluble in water, methanol, 100 % ethanol or acetonitrile.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies: I. Albrecht, et al.; J. Clin. Invest. 125, 4612 (2015), Application(s): Skeletal muscle cell culture, Abstract — Full Text
Structures and activities of protease inhibitors of microbial origin: H. Umezawa; Meth. Enzymol. 45, 678 (1976), Abstract
Antipain, a new protease inhibitor isolated from actinomycetes: H. Suda, et al.; J. Antibiot. 25, 263 (1972), Abstract

Related Products

Leupeptin (synthetic)

ALX-260-009

Cathepsin B inhibitor

19 citations

Purity	≥97% (HPLC)
Source	Synthetic.

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Antipain

ALX-260-093

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