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Amlodipine

BML-CA202

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Ca²⁺ channel blocker

Amlodipine is a third generation L-type calcium channel blocker with a unique spectrum of actions, over and above its antihypertensive activity which include stimulation of NO synthase, inhibition of monocyte-endothelial adhesion, inhibition of oxidative stress and sustained duration of action.

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Product Details

Appearance	Almost white crystal powder
CAS	88150-42-9
Couple Target	Calcium channel
Couple Type	Blocker
Formula	C₂₀H₂₅ClN₂O₅
MW	408.9
Purity	≥98% (Assay)
Solubility	Soluble in methanol, DMSO (25mg/ml), 100% ethanol (25mg/ml), dimethyl formamide (25mg/ml) or chloroform.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The influence of cold temperature on cellular excitability of hippocampal networks: de la Peña, E., Mälkiä, A., et al.; PLoS One 7, e52475 (2013), Abstract
Postnatal expression of an apamin-sensitive k(ca) current in vestibular calyx terminals: Meredith, F. L., Li, G. Q., et al.; J. Membr. Biol. 244, 81 (2011), Abstract
Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine: R. P. Mason, et al.; Arterioscler. Thromb. Vasc. Biol. 23, 2155 (2003), Abstract — Full Text
A calcium channel blocker activates both ecto-5(‘)-nucleotidase and NO synthase in HUVEC: Y. Asano, et al.; Biochem. Biophys. Res. Commun. 311, 625 (2003), Abstract
Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction: T. Yu, et al.; Hypertension 42, 329 (2003), Abstract — Full Text
A comparative assessment of the duration of action of amlodipine and nifedipine GITS in normotensive subjects: S. Ueda, et al.; Br. J. Clin. Pharmacol. 36, 561 (1993), Abstract — Full Text

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Amlodipine

BML-CA202

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