Home Shop 5-(N-Ethyl-N-isopropyl)amiloride

5-(N-Ethyl-N-isopropyl)amiloride

ALX-550-266

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Na⁺/H+ antiporter inhibitor

Selective inhibitor of the Na/H antiporter.

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Product Details

Alternative Name	5-(N-Ethyl-N-isopropyl)amiloride, EIPA
Appearance	Pale yellow to green solid.
CAS	1154-25-2
Couple Target	Na+/H+ antiporter
Couple Type	Inhibitor
Formula	C₁₁H₁₈ClN₇O
Identity	Determined by NMR.
MW	299.8
Purity	≥95% (HPLC)
Solubility	Slightly soluble in Acetonitrile/DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Magnetic colloidal nanoformulations to remotely trigger mechanotransduction for osteogenic differentiation: M. Estévez, et al.; J. Colloid Interface Sci. 15, 664 (2024), Abstract
Low pH Facilitates Heterodimerization of Mutant Isocitrate Dehydrogenase IDH1-R132H and Promotes Production of 2-Hydroxyglutarate: Sesanto, R., Kuehn, J. F., et al.; Biochemistry 60, 1983 (2021), Abstract
Sodium Citrate Increases Expression and Flux of Mg2+ Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells: Y. Takashina, et al.; Nutrients 10, E1345 (2018), Abstract
Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection: Serfass, J. M., Takahashi, Y., et al.; J. Biol. Chem. 292, 10097 (2017), Abstract
Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation: Ulmschneider, B., Grillo-Hill, B. K., et al.; J. Cell Biol. 215, 345 (2016), Abstract
Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity: S. Watanabe, et al.; Cell Death Dis. 5, e1497 (2014), Application(s): Treatment of N2a mouse neuroblastoma cells, Abstract — Full Text
Uptake of Shiga-toxigenic Escherichia coli SubAB by HeLa cells requires an actin- and lipid raft-dependent pathway: Nagasawa, S., Ogura, K., et al.; Cell. Microbiol. 16, 1582 (2014), Abstract
The signalling imprints of nanoparticle uptake by bone marrow derived dendritic cells: L. Karlson Tde, et al.; Methods 60, 275 (2013), Abstract
Regulation of intracellular pH in crypt cells from rabbit distal colon: S.L. Abrahamse, et al.; Am. J. Physiol. 267, G409 (1994), Abstract
Apical membrane Na+/H+ exchange in rat medullary thick ascending limb. pH-dependence and inhibition by hyperosmolality: B.A. Watts III & D.W. Good; J. Biol. Chem. 269, 20250 (1994), Abstract — Full Text

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