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2-Bromoaldisine

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Inhibitor of the Raf/MEK-1/MAPK cascade

Inhibitor of the Raf/MEK-1/MAPK cascade (IC₅₀= 539nM).

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Appearance	White to off-white powder.
CAS	96562-96-8
Couple Target	MAPK
Couple Type	Inhibitor
Formula	C₈H₇BrN₂O₂
Identity	Identity determined by 1H-NMR and ESI-MS.
MW	243.1
Purity	≥96% (HPLC)
Solubility	Soluble in DMSO or 100% ethanol.
Source	Isolated from sponge Pseudaxynissa sp.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

CD40L mediated alternative NFκB-signaling induces resistance to BCR-inhibitors in patients with mantle cell lymphoma: H. Rauert-Wunderlich, et al.; Cell Death Dis. 9, 86 (2018), Abstract — Full Text
Stereoselective synthesis of (Z)-axino- and (Z)-debromoaxinohydantoin: F. Tutino, et al.; Tetrahedron 65, 2372 (2009)
Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa: A. Aiello, et al.; Bioorg. Med. Chem. 14, 17 (2006), Abstract
Synthesis and target identification of hymenialdisine analogs: Y. Wan, et al.; Chem. Biol. 11, 247 (2004), Abstract
Anti-Cancer Metabolites from Marine Sponges: D. Tasdemir; Biodiversity: Biomolecular Aspects of Biodiversity and Innovative Utilization , 187 (2002), (Book), Abstract
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem. 45, 529 (2002), Abstract
Total syntheses of hymenialdisine and debromohymenialdisine: Stereospecific construction of the 2-amino-4-oxo-2-imidazolin-5(Z)-disubstituted y ylidene ring system: H. Annoura & T. Tatsuoka; THL 36, 413 (1995)
Marine natural products: pyrrololactams from several sponges: F.J. Schmitz, et al.; J. Nat. Prod. 48, 47 (1985), Abstract

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