iNOS inhibitor
A slow, tight binding and highly selective inhibitor of inducible nitric oxide synthase (iNOS/NOS II) in vitro and in vivo. Binds tightly to iNOS with a Kd of 7nM. In contrast, inhibition of nNOS and eNOS is weaker and rapidly reversible with Ki values of 2 and 50µM respectively. Inhibits tumor growth in vivo. Prevents circulatory failure but not organ injury induced by endotoxin. Displays protective effects in oxygen-deprived brain slices.
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Product Details
Appearance |
White to off-white powder. |
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CAS |
214358-33-5 |
Couple Target |
NOS |
Couple Type |
Inhibitor |
Formula |
C10H15N3 . 2HCl |
Identity |
Determined by NMR. |
MW |
250.17 |
Purity |
≥95% (TLC) |
Solubility |
Soluble in water (up to 25mg/ml), methanol or DMSO. |
Source |
Synthetic. |
Handling & Storage
Use/Stability |
As indicated on product label or CoA when stored as recommended. |
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Handling |
Hygroscopic. |
Short Term Storage |
-20°C |
Long Term Storage |
-20°C |
Shipping |
Ambient Temperature |
Regulatory Status |
RUO – Research Use Only |
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- Differential Effects of D9 Tetrahydrocannabinol (THC)- and Cannabidiol (CBD)-Based Cannabinoid Treatments on Macrophage Immune Function In Vitro and on Gastrointestinal Inflammation in a Murine Model: Z. Yekhtin, et al.; Biomedicines 10, 1793 (2022), Abstract
- The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases: R. Marullo, et al.; Sci. Adv. 7, eabg1964 (2021), Abstract
- Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes: Karki, R., Sharma, B. R., et al.; Cell 184, 149 (2021), Application(s): In Vitro, Abstract
- A high-performance genetically encoded fluorescent biosensor for imaging physiological peroxynitrite: Chen, Z., Zhang, S., et al.; Cell Chem. Biol. 28, 1542 (2021), Abstract
- Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth: R.K.S. Malireddi, et al.; Immunohorizons 5, 568 (2021), Abstract
- GPR30 Attenuates Myocardial Fibrosis in Diabetic Ovariectomized Female Rats: Role of iNOS Signaling: X. Wang, et al.; DNA Cell Biol. 37, 821 (2018), Abstract
- Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects against Corticosterone-Induced Insults in PC12 Cells: J. Zhao, et al.; Int. J. Mol. Sci. 16, 22795 (2015), Application(s): Cell Culture, Abstract — Full Text
- Pretreatment with Relaxin Does Not Restore NO-Mediated Modulation of Calcium Signal in Coronary Endothelial Cells Isolated from Spontaneously Hypertensive Rats: S. Nistri, et al.; Molecules 20, 9524 (2015), Application(s): Cell Culture, Abstract — Full Text
- Levosimendan inhibits interleukin-1β-induced apoptosis through activation of Akt and inhibition of inducible nitric oxide synthase in rat cardiac fibroblasts: M. Okada, et al.; Eur. J. Pharmacol. 769, 86 (2015), Application(s): Cell culture , Abstract
- Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms: E. Wang, et al.; Anesthesiology 114, 603 (2010), Abstract — Full Text
- Effects of 1400W, a potent selective inducible NOS inhibitor, on histamine- and leukotriene D4-induced relaxation of isolated guinea pig nasal mucosa: Y. Chiba, et al.; Nitric Oxide 15, 142 (2006), Abstract
- Addition of nitric oxide donor S-nitroso-N-acetylcysteine to selective iNOS inhibitor 1400W further improves contractile function in reperfused skeletal muscle: J.U. Barker, et al.; Microsurgery 25, 338 (2005), Abstract
- 1400W, a potent selective inducible NOS inhibitor, improves histopathological outcome following traumatic brain injury in rats: M. Jafarian-Tehrani, et al.; Nitric Oxide 12, 61 (2005), Abstract
- IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis: Kaplin, A. I., Deshpande, D. M., et al.; J. Clin. Invest. 115, 2731 (2005), Abstract
- Increased vasoconstriction to noradrenaline by 1400W, inhibitor of iNOS, in rats with streptozotocin-induced diabetes: X. Cheng & C.C. Pang; Eur. J. Pharmacol. 484, 263 (2004), Abstract
- Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms: R. Fedorov, et al.; J. Biol. Chem. 278, 45818 (2003), Abstract — Full Text
- Nitric Oxide Ameliorates Hydrophobic Bile Acid-induced Apoptosis in Isolated Rat Hepatocytes by Non-mitochondrial Pathways: E. Gumpricht, et al.; J. Biol. Chem. 277, 25823 (2002), Abstract — Full Text
- Nitric oxide synthases: structure, function and inhibition: W.K. Alderton, et al.; Biochem. J. 357, 593 (2001), Review, Abstract — Full Text
- The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol. 58, 1026 (2000), Abstract — Full Text
- 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo: E.P. Garvey, et al.; J. Biol. Chem. 272, 4959 (1997), Abstract — Full Text
- Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon: F. Laszlo & B.J.R. Whittle; Eur. J. Pharmacol. 334, 99 (1997), Abstract
- Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor: L.L. Thomsen, et al.; Cancer Res. 57, 3300 (1997), Abstract
Last modified: May 29, 2024
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