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1400W . dihydrochloride

ALX-270-073

22 citations

  • ALX-270-073-M005   —   5 mg
    $77.00
  • ALX-270-073-M025   —   25 mg
    $227.00

A slow, tight binding and highly selective inhibitor of inducible nitric oxide synthase (iNOS/NOS II) in vitro and in vivo. Binds tightly to iNOS with a Kd of 7nM. In contrast, inhibition of nNOS and eNOS is weaker and rapidly reversible with Ki values of 2 and 50µM respectively. Inhibits tumor growth in vivo. Prevents circulatory failure but not organ injury induced by endotoxin. Displays protective effects in oxygen-deprived brain slices.

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Regulatory Status

RUO – Research Use Only


Last modified: May 29, 2024