α-synuclein is a major component of Parkinson’s disease aggregates and is implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders. α-synuclein accumulates in the brains of sporadic Parkinson’s disease patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of Parkinson’s disease. α-synuclein appears to associate with other proteins that aggregate and is found in β-amyloid plaques and neuritic tangles in Alzheimer’s disease.
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