Home Shop (±)-Verapamil . hydrochloride

(±)-Verapamil . hydrochloride

ALX-550-306

Datasheet
Manual
SDS
CofA

Already have an account?

Ca²⁺ channel inhibitor

Blocks slow voltage-sensitive L-type Ca²⁺channels. Adrenergic antagonist. Inhibits platelet-activating factor and PMA-stimulated prostaglandin production in Kupffer cells. Induces apoptosis. In vitro resistance modifier in drug resistant human tumor cell lines.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	5-[(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-valeronitrile . HCl
Appearance	White crystalline powder.
CAS	152-11-4
Couple Target	Calcium channel
Couple Type	Inhibitor
Formula	C₂₇H₃₈N₂O₄ . HCl
Identity	Determined by IR.
MI	14: 9950
MW	454.6 . 36.5
Purity	≥99% (HPLC)
RTECS	YV8320000
Solubility	Soluble in 100% ethanol (26mg/ml), methanol or water (83mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

In vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes: M. Takiyama, et al.; Xenobiotica 52, 511 (2022), Abstract
Targeting KRAS4A splicing through the RBM39/DCAF15 pathway inhibits cancer stem cells: W. C. Chen, et al.; Nat. Commun. 12, 4288 (2021), Abstract
Pharmacokinetic study of Ninjin’yoeito: Absorption and brain distribution of Ninjin’yoeito ingredients in mice: T. Matsumoto, et al.; J. Ethnopharmacol. 279, 114332 (2021), Abstract
Regulation of i>KRAS4A/B/i> splicing in cancer stem cells by the RBM39 splicing complex: Chen, W., To, M. D., et al.; bioRxiv , (2019)
Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer: Morad, S. A. F., Davis, T. S., et al.; Biochem. Pharmacol. 130, 21 (2017), Abstract
Short-term exposure to L-type calcium channel blocker, verapamil, alters the expression pattern of calcium-binding proteins in the brain of goldfish, Carassius auratus: N.V. Palande, et al.; Comp. Biochem. Physiol. C: Tocicol. Pharmacol. 176-177, 31 (2015), Application(s): Cell culture in fish, Abstract
Overnutrition induces β-cell differentiation through prolonged activation of β-cells in zebrafish larvae: Li, M., Maddison, L. A., et al.; Am. J. Physiol. Endocrinol. Metab. 306, E799 (2014), Abstract
Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1: Baskin, R., Sayeski, P. P., et al.; Cell. Signal. 24, 435 (2012), Abstract
Hyperthermia and verapamil inhibit the growth of human colon cancer xenografts in vivo through apoptosis: I.B. Shchepotin, et al.; Anticancer Res. 17, 2213 (1997), Abstract
Neuron degeneration induced by verapamil and attenuated by EGb761: L. Zhu, et al.; J. Basic Clin. Physiol. Pharmacol. 8, 301 (1997), Abstract

Resources

Brochures

Metabolism

Download Resource

Brochures

Cellular Therapy

Download Resource

Brochures

Cardiovascular Research

Download Resource

Brochures

Drug Discovery

Download Resource

Brochures

AMPIVIEW® RNA Probes

Download Resource

Brochures

Immuno-Oncology

Download Resource

Brochures

AMPIGENE® PCR Solutions

Download Resource

Brochures

Bioprocess

Download Resource

Related Products

(+)-Aphidicolin

BML-CC101

Reversible inhibitor of DNA polymerase a and d

21 citations

CAS	38966-21-1
Couple Type	Inhibitor
Purity	≥98% (TLC)

(+)-Bicuculline

ALX-550-515

GABA_A receptor antagonist

7 citations

Alternative Name	D-Bicuculline
CAS	485-49-4
Couple Type	Inhibitor, Ligand
Purity	≥98% (HPLC)

(+)-Catechin . monohydrate

ALX-385-017

Free radical scavenger

10 citations

Alternative Name	(+)-3,3’,4’,5,7-Flavanpentol . H2O
CAS	225937-10-0
Purity	≥98% (HPLC)

(+)-Egenine

ALX-350-362

6 citations

Alternative Name	6-(6-Methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-6,8-dihydrofuro[3,4-E][1,3]benzodioxol-8-ol, (+)-Decumbensine
CAS	6883-44-9
Purity	≥98% (HPLC)

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

(±)-Verapamil . hydrochloride

ALX-550-306

Product Details

Handling & Storage

Resources

Metabolism

Cellular Therapy

Cardiovascular Research

Drug Discovery

AMPIVIEW® RNA Probes

Immuno-Oncology

AMPIGENE® PCR Solutions

Bioprocess

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project